The effectiveness of chemotherapy is largely limited by drug resistance. In the past few
decades, modulation of anticancer drug resistance plays little role in benefit of clinical …

Simple Summary Chemotherapy resistance is a common occurrence during cancer
treatment that cancer researchers are attempting to understand and overcome. Mitochondria …

The mitochondrion is an organelle that plays a vital role in energy production, cytoplasmic
protein degradation and cell death. Mitophagy is an autophagic procedure that specifically …

Mitophagy, the selective degradation of mitochondria via the autophagic pathway, is a vital
mechanism of mitochondrial quality control in cells. Mitophagy is responsible for the removal …

Background Mitophagy refers to the selective self‐elimination of mitochondria under
damaged or certain developmental conditions. As an important regulatory mechanism to …

Mitophagy is a selective form of macroautophagy in which dysfunctional and damaged
mitochondria can be efficiently degraded, removed and recycled through autophagy …

Many anticancer agents exert cytotoxicity and trigger apoptosis through the induction of
mitochondrial dysfunction. Mitophagy, as a key mitochondrial quality control mechanism …

Mitophagy is a selective form of macro-autophagy in which mitochondria are selectively
targeted for degradation in autophagolysosomes. Mitophagy can have the beneficial effect …

abstract Mitophagy is a conserved, mitochondria-specific autophagic clearance process. We
recently discovered an intricate regulatory network that balances mitophagy with …

In the past years, we have learnt that tumors co-evolve with their microenvironment, and that
the active interaction between cancer cells and stromal cells plays a pivotal role in cancer …