[HTML][HTML] Design and prediction of aptamers assisted by in silico methods
SJ Lee, J Cho, BH Lee, D Hwang, JW Park - Biomedicines, 2023 - mdpi.com
An aptamer is a single-stranded DNA or RNA that binds to a specific target with high binding
affinity. Aptamers are developed through the process of systematic evolution of ligands by …
affinity. Aptamers are developed through the process of systematic evolution of ligands by …
[HTML][HTML] Artificial intelligence in aptamer–target binding prediction
Aptamers are short single-stranded DNA, RNA, or synthetic Xeno nucleic acids (XNA)
molecules that can interact with corresponding targets with high affinity. Owing to their …
molecules that can interact with corresponding targets with high affinity. Owing to their …
APIPred: An XGBoost-Based Method for Predicting Aptamer–Protein Interactions
Aptamers are single-stranded DNA or RNA oligos that can bind to a variety of targets with
high specificity and selectivity and thus are widely used in the field of biosensing and …
high specificity and selectivity and thus are widely used in the field of biosensing and …
Computational predictive approaches for interaction and structure of aptamers
Aptamers are short single-strand sequences that can bind to their specific targets with high
affinity and specificity. Usually, aptamers are selected experimentally via systematic …
affinity and specificity. Usually, aptamers are selected experimentally via systematic …
[HTML][HTML] AptaTrans: a deep neural network for predicting aptamer-protein interaction using pretrained encoders
Background Aptamers, which are biomaterials comprised of single-stranded DNA/RNA that
form tertiary structures, have significant potential as next-generation materials, particularly …
form tertiary structures, have significant potential as next-generation materials, particularly …
In silico strategies for modeling RNA aptamers and predicting binding sites of their molecular targets
A Escamilla-Gutiérrez, RM Ribas-Aparicio… - … nucleotides & nucleic …, 2021 - Taylor & Francis
RNA aptamers are single-stranded nucleic acids of 20–100 nucleotides, with high sensitivity
and specificity against particular molecular targets. In vitro production and selection of …
and specificity against particular molecular targets. In vitro production and selection of …
In silico design of novel aptamers utilizing a hybrid method of machine learning and genetic algorithm
Aptamers can be regarded as efficient substitutes for monoclonal antibodies in many
diagnostic and therapeutic applications. Due to the tedious and prohibitive nature of SELEX …
diagnostic and therapeutic applications. Due to the tedious and prohibitive nature of SELEX …
[HTML][HTML] Predicting aptamer sequences that interact with target proteins using an aptamer-protein interaction classifier and a Monte Carlo tree search approach
G Lee, GH Jang, HY Kang, G Song - PloS one, 2021 - journals.plos.org
Oligonucleotide-based aptamers, which have a three-dimensional structure with a single-
stranded fragment, feature various characteristics with respect to size, toxicity, and …
stranded fragment, feature various characteristics with respect to size, toxicity, and …
[HTML][HTML] Methods and applications of in silico aptamer design and modeling
AA Buglak, AV Samokhvalov, AV Zherdev… - International journal of …, 2020 - mdpi.com
Aptamers are nucleic acid analogues of antibodies with high affinity to different targets, such
as cells, viruses, proteins, inorganic materials, and coenzymes. Empirical approaches allow …
as cells, viruses, proteins, inorganic materials, and coenzymes. Empirical approaches allow …
In silico approach for Post-SELEX DNA aptamers: A mini-review
Aptamers are short oligonucleotides that possess high specificity and affinity against their
target. Generated via Systematic Evolution of Ligands by Exponential Enrichment,(SELEX) …
target. Generated via Systematic Evolution of Ligands by Exponential Enrichment,(SELEX) …