Significance: Synaptic degeneration, an early pathological feature in Alzheimer's disease
(AD), is closely correlated to impaired cognitive function and memory loss. Recent studies …

Alzheimer's disease (AD) is characterized by brain deposition of amyloid plaques and tau
neurofibrillary tangles along with steady cognitive decline. Synaptic damage, an early …

Alzheimer's disease (AD) is a chronic neurodegenerative disorder, in which multiple risk
factors converge. Despite the complexity of the etiology of the disease, synaptic failure is the …

Recent studies of postmortem brains from Alzheimer's disease (AD) patients and transgenic
mouse models of AD suggest that oxidative damage, induced by amyloid β (Aβ), is …

Neuronal transmission and functional synapses require mitochondria, which are mainly
involved in the generation of energy (ATP and NAD+), regulation of cell signaling and …

Synaptic dysfunction and the loss of synapses are early pathological features of Alzheimer's
disease (AD). Synapses are sites of high energy demand and extensive calcium …

Alzheimer's disease (AD) is characterized by cognitive impairment and the presence of
neurofibrillary tangles and senile plaques in the brain. Neurofibrillary tangles are composed …

Synaptic pathology and mitochondrial oxidative damage are early events in Alzheimer's
disease (AD) progression. Loss of synapses and synaptic damage are the best correlates of …

Synapses are sites of high energy demand which are dependent on high levels of
mitochondrial derived adenosine triphosphate. Mitochondria within synaptic structures are …

Mitochondria play a pivotal role in bioenergetics and respiratory functions, which are
essential for the numerous biochemical processes underpinning cell viability. Mitochondrial …