[HTML][HTML] Análisis farmacogenético de la cinética de absorción de ciclosporina en una población española de pacientes trasplantados cardíacos
BI Tejera, MDA Rubio, J Martínez-Moreno… - Farmacia …, 2009 - Elsevier
Objetivo Determinar el papel de polimorfismos de nucleótido único localizados en los genes
MDR1, CYP3A4 y CYP3A5 sobre la cinética de absorción de ciclosporina en pacientes …
MDR1, CYP3A4 y CYP3A5 sobre la cinética de absorción de ciclosporina en pacientes …
Pharmacogenetic analysis of the absorption kinetics of cyclosporine in a population of Spanish cardiac transplant patients
BI Tejera, MDA Rubio, J Martínez-Moreno… - Farmacia Hospitalaria …, 2009 - Elsevier
Objective To determine how single nucleotide polymorphisms located on genes MDR1,
CYP3A4, and CYP3A5 affect the absorption kinetics of cyclosporine in cardiac transplant …
CYP3A4, and CYP3A5 affect the absorption kinetics of cyclosporine in cardiac transplant …
[PDF][PDF] Análisis farmacogenético de la ciclosporina en relación a los factores farmacocinéticos-farmacodinámicos y la incidencia de rechazo agudo tras el trasplante …
B Isla Tejera - 2008 - digibug.ugr.es
Introducción: El trasplante cardíaco continúa siendo el tratamiento definitivo en pacientes
con insuficiencia cardíaca terminal. La ciclosporina (CsA) es uno de los fármacos más …
con insuficiencia cardíaca terminal. La ciclosporina (CsA) es uno de los fármacos más …
Variabilidad farmacocinética en pacientes con trasplante renal tratados con ciclosporina evaluación de variantes genéticas como covariables
FJ Corvalán Nazal - 2017 - repositorio.udec.cl
Ciclosporina (CsA) es un fármaco inmunosupresor utilizado para prevenir el rechazo de
órganos en pacientes trasplantados. Sin embargo, esta droga se caracteriza por poseer un …
órganos en pacientes trasplantados. Sin embargo, esta droga se caracteriza por poseer un …
Population pharmacokinetics of cyclosporine in kidney and heart transplant recipients and the influence of ethnicity and genetic polymorphisms in the MDR‐1 …
DA Hesselink, T van Gelder… - Clinical …, 2004 - Wiley Online Library
Objective Our objective was to determine the relationship between single nucleotide
polymorphisms (SNPs) in the multidrug resistance 1 (MDR‐1) gene and the cytochrome …
polymorphisms (SNPs) in the multidrug resistance 1 (MDR‐1) gene and the cytochrome …
GENETIC POLYMORPHISMS OF CYP3A5 AND MDR1 ON CYCLOSPORINE CONCENTRATION IN THE EARLY STAGE AFTER RENAL TRANSPLANTATION
N AZARPIRA, HSA MALEK, S BEHZADI - 2008 - sid.ir
Background & Aims: The immunosuppressive drug CYCLOSPORINE with a narrow
therapeutic range and variable pharmacokinetic characteristics among individuals is a …
therapeutic range and variable pharmacokinetic characteristics among individuals is a …
Polymorphisms of multidrug resistance gene (MDR1) and cyclosporine absorption in de novo renal transplant patients
CJ Foote, W Greer, B Kiberd, A Fraser, J Lawen… - …, 2007 - journals.lww.com
Background. Several single nucleotide polymorphisms (SNPs) in the multidrug resistance
(MDR1) gene may play a role in the interindividual variation of cyclosporine A (CsA) …
(MDR1) gene may play a role in the interindividual variation of cyclosporine A (CsA) …
GENETIC CONTROL OF CICLOSPORIN ABSORPTION
A Jorga, A Johnston, S Wilson, D Holt… - …, 2004 - journals.lww.com
Aims: Ciclosporin is a narrow therapeutic index drug and has highly variable absorption.
Intestinal cytochrome P450 and P glycoprotein both play important roles in the intestinal …
Intestinal cytochrome P450 and P glycoprotein both play important roles in the intestinal …
CYP3A5 and MDR1 Genetic Polymorphisms and Cyclosporine Pharmacokinetics After Renal Transplantation
D Anglicheau, E Thervet, I Etienne… - Clinical …, 2004 - Wiley Online Library
Background The immunosuppressive drug cyclosporine (INN, ciclosporin), whose
pharmacokinetic characteristics vary greatly among individuals, is a substrate for …
pharmacokinetic characteristics vary greatly among individuals, is a substrate for …
Genetic polymorphisms in MDR1 and CYP3A4 genes in Asians and the influence of MDR1 haplotypes on cyclosporin disposition in heart transplant recipients
B Chowbay, S Cumaraswamy, YB Cheung… - Pharmacogenetics …, 2003 - journals.lww.com
Abstract Intestinal cytochrome P 450 3A4 (CYP3A4) and P-glycoprotein (P-gp) both play a
vital role in the metabolism of oral cyclosporine (CsA). We investigated the genetic …
vital role in the metabolism of oral cyclosporine (CsA). We investigated the genetic …