Glycyrrhizic acid suppresses 1, 2‐dimethylhydrazine‐induced colon tumorigenesis in Wistar rats: Alleviation of inflammatory, proliferation, angiogenic, and apoptotic …

R Khan, MU Rehman, AQ Khan, M Tahir… - Environmental …, 2018 - Wiley Online Library
Objectives Colon cancer is the major health disease related with high mortality. Glycyrrhizic
acid (GA) is an active constituent of licorice with anti‐inflammatory and anticarcinogenesis …

Ursolic acid inhibits nuclear factor-κB activation induced by carcinogenic agents through suppression of IκBα kinase and p65 phosphorylation: correlation with down …

S Shishodia, S Majumdar, S Banerjee, BB Aggarwal - Cancer research, 2003 - AACR
The process of tumorigenesis requires cellular transformation, hyperproliferation, invasion,
angiogenesis, and metastasis. Several genes that mediate these processes are regulated …

Luteolin inhibits the nuclear factor-κB transcriptional activity in Rat-1 fibroblasts

SH Kim, KJ Shin, D Kim, YH Kim, MS Han… - Biochemical …, 2003 - Elsevier
Flavonoids are natural polyphenolic compounds that have anti-inflammatory, cytoprotective
and anticarcinogenic effects. In this study, we investigated the effects of several flavonoids …

Inhibitory effect of luteolin on TNF-α-induced IL-8 production in human colon epithelial cells

JA Kim, DK Kim, OH Kang, YA Choi, HJ Park… - International …, 2005 - Elsevier
Interleukin (IL)-8 plays a central role in the initiation and maintenance of inflammatory
responses in the inflammatory bowel disease. The proinflammatory cytokine-mediated …

Ellagic acid inhibits proliferation and induced apoptosis via the Akt signaling pathway in HCT-15 colon adenocarcinoma cells

S Umesalma, P Nagendraprabhu… - Molecular and cellular …, 2015 - Springer
Chemoprevention is regarded as one of the most promising and realistic approaches in the
prevention of human cancer. Ellagic acid (EA) has been known for its chemopreventive …

Anti-proliferate and pro-apoptotic effects of 2, 3-dihydro-3, 5-dihydroxy-6-methyl-4H-pyranone through inactivation of NF-κB in human colon cancer cells

JO Ban, IG Hwang, TM Kim, BY Hwang, US Lee… - Archives of Pharmacal …, 2007 - Springer
Many natural compounds have been shown to prevent cancer cell growth through the redox
regulation of transcription factors. NF-κB, a redox transcription factor, has been implicated in …

Luteolin, a bioflavonoid inhibits Azoxymethane-induced colorectal cancer through activation of Nrf2 signaling

AK Pandurangan, SK Ananda Sadagopan… - Toxicology …, 2014 - Taylor & Francis
Colorectal cancer (CRC) is now perceived as a multistep process characterized by the
accumulation of genetic alterations in oncogenes and tumor suppressor genes. Plant …

Polyphenols as cancer chemopreventive agents

GD Stoner, H Mukhtar - Journal of Cellular Biochemistry, 1995 - Wiley Online Library
This article summarizes available data on the chemopreventive efficacies of tea
polyphenols, curcumin and ellagic acid in various model systems. Emphasis is placed upon …

Anti-inflammatory effects of iridoid glycosides fraction of Folium syringae leaves on TNBS-induced colitis in rats

X Liu, J Wang - Journal of Ethnopharmacology, 2011 - Elsevier
AIM OF THE STUDY: To investigate the effects and the protective mechanism of iridoid
glycosides (IG) enriched from Folium syringae leaves on ulcerative colitis (UC) model …

Effects of Ginkgo biloba Extract on Inflammatory Mediators (SOD, MDA, TNF‐α, NF‐κBp65, IL‐6) in TNBS‐Induced Colitis in Rats

YH Zhou, JP Yu, YF Liu, XJ Teng, M Ming… - Mediators of …, 2006 - Wiley Online Library
Inflammatory mediators play a criticial role in ulcerative colitis immune and inflammatory
processes. The aim of the study was to investigate the effects of Ginkgo biloba extract on …