Hyperhomocysteinemia: impact on neurodegenerative diseases

M Sharma, M Tiwari, RK Tiwari - Basic & clinical pharmacology …, 2015 - Wiley Online Library
Neurodegenerative diseases are the diseases of the central nervous system with various
aetiology and symptoms. Dementia, Alzheimer's disease (AD), Parkinson's disease (PD) …

[HTML][HTML] The controversial role of homocysteine in neurology: from labs to clinical practice

R Moretti, P Caruso - International journal of molecular sciences, 2019 - mdpi.com
Homocysteine (Hcy) is a sulfur-containing amino acid that is generated during methionine
metabolism. Physiologic Hcy levels are determined primarily by dietary intake and vitamin …

Homocysteine, vitamin determinants and neurological diseases.

R Ientile, M Curro, N Ferlazzo, S Condello… - Frontiers in …, 2010 - europepmc.org
This review focuses on the putative role of hyper-homocysteinemia in the pathogenesis of
different diseases affecting the nervous system, including stroke, Alzheimer's disease …

Role of homocysteine in cognitive impairement and Alzheimer's disease

S Bhargava, A Bhandari, S Choudhury - Indian Journal of Clinical …, 2018 - Springer
A high circulating concentration of the non proteinogenic amino acid homocysteine has
been implicated as a risk factor for Alzheimer's Disease and its prodromal stage, mild …

Homocysteine: a biomarker in neurodegenerative diseases

W Herrmann, R Obeid - Clinical chemistry and laboratory medicine, 2011 - degruyter.com
Diseases of the central nervous system are found in patients with severe
hyperhomocysteinemia (HHcy). Epidemiological studies show a positive, dose-dependent …

[HTML][HTML] Homocysteine, cognitive functions, and degenerative dementias: state of the art

S Luzzi, V Cherubini, L Falsetti, G Viticchi, M Silvestrini… - Biomedicines, 2022 - mdpi.com
There is strong evidence that homocysteine is a risk factor not only for cerebrovascular
diseases but also for degenerative dementias. A recent consensus statement renewed the …

[HTML][HTML] Involvements of hyperhomocysteinemia in neurological disorders

M Cordaro, R Siracusa, R Fusco, S Cuzzocrea… - Metabolites, 2021 - mdpi.com
Homocysteine (HCY), a physiological amino acid formed when proteins break down, leads
to a pathological condition called hyperhomocysteinemia (HHCY), when it is over a definite …

Homocysteine and brain atrophy

PS Sachdev - Progress in Neuro-Psychopharmacology and …, 2005 - Elsevier
Homocysteine (Hcy) has been implicated as a risk factor for vascular disease as well as
brain atrophy. There is evidence to implicate Hcy in increased oxidative stress, DNA …

The relationship between hyperhomocysteinemia and neurodegeneration

F Bonetti, G Brombo, G Zuliani - Neurodegenerative disease …, 2016 - Taylor & Francis
Homocysteine (Hcy) is a key junction in methionine metabolism. In inherited forms of
hyperhomocysteinemia patients develop early vascular damage and cognitive decline …

Hyperhomocysteinemia: clinical insights

F Al Mutairi - Journal of central nervous system disease, 2020 - journals.sagepub.com
Homocysteine (Hcy) is a sulfhydryl-containing amino acid, and intermediate metabolite
formed in metabolising methionine (Met) to cysteine (Cys); defective Met metabolism can …