The treatment of Alzheimer's disease (AD) with cholinesterase inhibitors (ChEIs) is based on
the cholinergic hypothesis. This hypothesis fails to account for the global nature of the …

In acute ischemic stroke, critical hypoperfusion is a frequent cause of hypoxic tissue injury:
As cerebral blood flow (CBF) falls below the ischemic threshold of 20 mL/100 mL/min …

Neuronal activity results in increased blood flow in the brain, a response named functional
hyperemia. Astrocytes play an important role in mediating this response. Neurotransmitters …

Alzheimer's disease (AD) is the most common neurodegenerative disease worldwide.
Histopathologically, AD presents with two hallmarks: neurofibrillary tangles (NFTs), and …

Alzheimer's disease (AD) is the most common type of dementia frequently responsible for
cognitive decline in the elderly. The etiology and molecular mechanism of AD pathogenesis …

Although the diverse triggers of AD are still under debate, the hypothesis of the contribution
of cerebrovascular deficiencies has emerged in recent years. Cerebrovascular dysfunction …

In vascular dementia (VaD) and Alzheimer's disease (AD), cerebral hypoperfusion and
blood‐brain barrier (BBB) leakiness contribute to brain damage. In this study, we have …

Patients with Alzheimer's disease have reduced cerebral blood flow measured by arterial
spin labelling magnetic resonance imaging, but it is unclear how this is related to amyloid-β …

Neurovascular dysfunction, including blood–brain barrier (BBB) breakdown and cerebral
blood flow (CBF) dysregulation and reduction, are increasingly recognized to contribute to …

A substantial body of evidence supports the hypothesis of a vascular component in the
pathogenesis of Alzheimer's disease (AD). Cerebral hypoperfusion and blood-brain barrier …