With the rapid development of nanomedicine, low side effects and high-efficiency green
antitumor approaches have attracted great attention. Herein, we report a strategy for the in …

Cancer cells rely on glycolysis to support a high proliferation rate. Metformin (Met) is a
promising drug for tumor treatment that targets hexokinase 2 (HK2) to block the glycolytic …

Consuming glucose by glucose oxidase (GOx) has attracted great interest in cancer
starvation therapy, but the therapeutic effect is severely limited by the tumor hypoxia …

Cancer cells can reprogram metabolic pathways to facilitate proliferation, metastasis,
biosynthesis, and chemoresistance. Metabolic reprogramming is currently considered as a …

The special metabolic traits of cancer cells and tumor‐associated macrophages (TAMs) in
the tumor microenvironment (TME) are promising targets for developing novel cancer …

While tumor-infiltrating cytotoxic T lymphocytes play a critical role in controlling tumor
development, they are generally impotent in an acidic tumor microenvironment. Systemic …

Remodeling tumor immune microenvironment (TIME) is an important strategy to lift the
immunosuppression and achieve immune normalization. In this work, a mannosylated …

A majority of cancers fail to respond to immunotherapy due to the immunosuppressive tumor
microenvironment (TME), and metabolic regulation of the TME has been a promising …

Integration of disease diagnosis and therapy in vivo by nanotechnology is a challenge in the
design of multifunctional nanocarriers. Herein, we report an intelligent and degradable …

As an increased product of high-rate aerobic glycolysis in tumors, lactate could regulate the
immunosuppressive tumor microenvironment (TME). A PEG-CDM surface modified, GSH …