Role of β2-integrins for homing and neovascularization capacity of endothelial progenitor cells

E Chavakis, A Aicher, C Heeschen, K Sasaki… - The Journal of …, 2005 - rupress.org
The mechanisms of homing of endothelial progenitor cells (EPCs) to sites of ischemia are
unclear. Here, we demonstrate that ex vivo–expanded EPCs as well as murine …

Functional disruption of α4 integrin mobilizes bone marrow–derived endothelial progenitors and augments ischemic neovascularization

G Qin, M Ii, M Silver, A Wecker, E Bord, H Ma… - The Journal of …, 2006 - rupress.org
The cell surface receptor α4 integrin plays a critical role in the homing, engraftment, and
maintenance of hematopoietic progenitor cells (HPCs) in the bone marrow (BM). Down …

A homing mechanism for bone marrow–derived progenitor cell recruitment to the neovasculature

H Jin, A Aiyer, J Su, P Borgstrom… - The Journal of …, 2006 - Am Soc Clin Investig
CD34+ bone marrow–derived progenitor cells contribute to tissue repair by differentiating
into endothelial cells, vascular smooth muscle cells, hematopoietic cells, and possibly other …

Endothelial progenitor cells and integrins: adhesive needs

F Caiado, S Dias - Fibrogenesis & tissue repair, 2012 - Springer
In the last decade there have been multiple studies concerning the contribution of
endothelial progenitor cells (EPCs) to new vessel formation in different physiological and …

Endothelial progenitor cell homing: prominent role of the IGF2-IGF2R-PLCβ2 axis

YS Maeng, HJ Choi, JY Kwon, YW Park… - Blood, The Journal …, 2009 - ashpublications.org
Homing of endothelial progenitor cells (EPCs) to the neovascular zone is now considered to
be an essential step in the formation of vascular networks during embryonic development …

[HTML][HTML] Fetal and adult hematopoietic stem cells require β1 integrin function for colonizing fetal liver, spleen, and bone marrow

AJ Potocnik, C Brakebusch, R Fässler - Immunity, 2000 - cell.com
Homing of hematopoietic stem cells (HSCs) into hematopoietic organs is a prerequisite for
the establishment of hematopoiesis during embryogenesis and after bone marrow …

CD34 Blood-Derived Human Endothelial Cell Progenitors

M Harraz, C Jiao, HD Hanlon, RS Hartley… - Stem …, 2001 - academic.oup.com
A subset of adult peripheral blood leukocytes functions as endothelial cell progenitors called
angioblasts. They can incorporate into the vasculature in animal models of …

Multistep nature of microvascular recruitment of ex vivo–expanded embryonic endothelial progenitor cells during tumor angiogenesis

P Vajkoczy, S Blum, M Lamparter… - The Journal of …, 2003 - rupress.org
Tissue neovascularization involves recruitment of circulating endothelial progenitor cells that
originate in the bone marrow. Here, we show that a class of embryonic endothelial …

Adherent platelets recruit and induce differentiation of murine embryonic endothelial progenitor cells to mature endothelial cells in vitro

H Langer, AE May, K Daub, U Heinzmann… - Circulation …, 2006 - Am Heart Assoc
The homing and differentiation mechanisms of endothelial progenitor cells (EPCs) at sites of
vascular lesions are unclear. To investigate whether platelets play a role in the recruitment …

Akt is a key modulator of endothelial progenitor cell trafficking in ischemic muscle

J Hur, CH Yoon, CS Lee, TY Kim, I Oh, KW Park… - Stem …, 2007 - academic.oup.com
Trafficking of transplanted endothelial progenitor cells (EPCs) to ischemic tissue is
enhanced by stromal‐derived factor 1 (SDF‐1) and vascular endothelial growth factor …