Recent clinical trends in Toll‐like receptor targeting therapeutics

MA Anwar, M Shah, J Kim, S Choi - Medicinal research reviews, 2019 - Wiley Online Library
Toll‐like receptors (TLRs) are germline‐encoded receptors that are central to innate and
adaptive immune responses. Owing to their vital role in inflammation, TLRs are rational …

New developments in Toll-like receptor targeted therapeutics

DJ Connolly, LAJ O'Neill - Current opinion in pharmacology, 2012 - Elsevier
Toll-like receptors (TLRs) play a crucial role in host defence and inflammation. Given that a
significant amount of evidence implicates TLRs in the pathogenesis of immune diseases …

Recent progress in the development of Toll-like receptor (TLR) antagonists

MC Patra, S Choi - Expert opinion on therapeutic patents, 2016 - Taylor & Francis
ABSTRACT Introduction: Pattern recognition receptors (PRRs) of the innate immune system
mediate and control the activation and progression of adaptive immunity. Toll-like receptors …

[HTML][HTML] Toll-like receptors as a therapeutic target in the era of immunotherapies

M Farooq, M Batool, MS Kim, S Choi - Frontiers in Cell and …, 2021 - frontiersin.org
Toll-like receptors (TLRs) are the pattern recognition receptors, which are activated by
foreign and host molecules in order to initiate the immune response. They play a crucial role …

Therapeutic targeting of Toll-like receptors for inflammatory and infectious diseases

LAJ O'Neill - Current opinion in pharmacology, 2003 - Elsevier
Roles for Toll-like receptors (TLRs) are emerging in conditions such as sepsis syndrome,
systemic lupus erythromatosis, rheumatoid arthritis and asthma, suggesting that the …

Prophylactic and therapeutic implications of toll‐like receptor ligands

M Hedayat, K Takeda, N Rezaei - Medicinal research reviews, 2012 - Wiley Online Library
The evolutionary conserved Toll‐like receptors (TLRs) are the first identified and best
characterized pattern recognition receptors (PRRs) which discriminate self from nonself …

Toll-like receptors: promising therapeutic targets for inflammatory diseases

A Achek, D Yesudhas, S Choi - Archives of pharmacal research, 2016 - Springer
The health of living organisms is constantly challenged by bacterial and viral threats. The
recognition of pathogenic microorganisms by diverse receptors triggers a variety of host …

The pharmacokinetics of Toll-like receptor agonists and the impact on the immune system

AL Engel, GE Holt, H Lu - Expert review of clinical pharmacology, 2011 - Taylor & Francis
Toll-like receptor (TLR) ligation activates both the innate and adaptive immune systems, and
plays an important role in antiviral and anti-tumor immunity. Therefore, a significant amount …

TLR based therapeutics

A Dunne, NA Marshall, KHG Mills - Current opinion in pharmacology, 2011 - Elsevier
Toll-like receptors (TLRs) play a crucial role in innate immune responses to infection.
Binding of agonists to TLRs promotes maturation of antigen presenting cells, such as …

[HTML][HTML] Toll-like receptor-targeted anti-tumor therapies: Advances and challenges

Y Yang, H Li, C Fotopoulou, P Cunnea… - Frontiers in …, 2022 - frontiersin.org
Toll-like receptors (TLRs) are pattern recognition receptors, originally discovered to
stimulate innate immune reactions against microbial infection. TLRs also play essential roles …