Recent clinical trends in Toll‐like receptor targeting therapeutics
Toll‐like receptors (TLRs) are germline‐encoded receptors that are central to innate and
adaptive immune responses. Owing to their vital role in inflammation, TLRs are rational …
adaptive immune responses. Owing to their vital role in inflammation, TLRs are rational …
New developments in Toll-like receptor targeted therapeutics
DJ Connolly, LAJ O'Neill - Current opinion in pharmacology, 2012 - Elsevier
Toll-like receptors (TLRs) play a crucial role in host defence and inflammation. Given that a
significant amount of evidence implicates TLRs in the pathogenesis of immune diseases …
significant amount of evidence implicates TLRs in the pathogenesis of immune diseases …
Recent progress in the development of Toll-like receptor (TLR) antagonists
ABSTRACT Introduction: Pattern recognition receptors (PRRs) of the innate immune system
mediate and control the activation and progression of adaptive immunity. Toll-like receptors …
mediate and control the activation and progression of adaptive immunity. Toll-like receptors …
[HTML][HTML] Toll-like receptors as a therapeutic target in the era of immunotherapies
Toll-like receptors (TLRs) are the pattern recognition receptors, which are activated by
foreign and host molecules in order to initiate the immune response. They play a crucial role …
foreign and host molecules in order to initiate the immune response. They play a crucial role …
Therapeutic targeting of Toll-like receptors for inflammatory and infectious diseases
LAJ O'Neill - Current opinion in pharmacology, 2003 - Elsevier
Roles for Toll-like receptors (TLRs) are emerging in conditions such as sepsis syndrome,
systemic lupus erythromatosis, rheumatoid arthritis and asthma, suggesting that the …
systemic lupus erythromatosis, rheumatoid arthritis and asthma, suggesting that the …
Prophylactic and therapeutic implications of toll‐like receptor ligands
M Hedayat, K Takeda, N Rezaei - Medicinal research reviews, 2012 - Wiley Online Library
The evolutionary conserved Toll‐like receptors (TLRs) are the first identified and best
characterized pattern recognition receptors (PRRs) which discriminate self from nonself …
characterized pattern recognition receptors (PRRs) which discriminate self from nonself …
Toll-like receptors: promising therapeutic targets for inflammatory diseases
The health of living organisms is constantly challenged by bacterial and viral threats. The
recognition of pathogenic microorganisms by diverse receptors triggers a variety of host …
recognition of pathogenic microorganisms by diverse receptors triggers a variety of host …
The pharmacokinetics of Toll-like receptor agonists and the impact on the immune system
Toll-like receptor (TLR) ligation activates both the innate and adaptive immune systems, and
plays an important role in antiviral and anti-tumor immunity. Therefore, a significant amount …
plays an important role in antiviral and anti-tumor immunity. Therefore, a significant amount …
TLR based therapeutics
A Dunne, NA Marshall, KHG Mills - Current opinion in pharmacology, 2011 - Elsevier
Toll-like receptors (TLRs) play a crucial role in innate immune responses to infection.
Binding of agonists to TLRs promotes maturation of antigen presenting cells, such as …
Binding of agonists to TLRs promotes maturation of antigen presenting cells, such as …
[HTML][HTML] Toll-like receptor-targeted anti-tumor therapies: Advances and challenges
Y Yang, H Li, C Fotopoulou, P Cunnea… - Frontiers in …, 2022 - frontiersin.org
Toll-like receptors (TLRs) are pattern recognition receptors, originally discovered to
stimulate innate immune reactions against microbial infection. TLRs also play essential roles …
stimulate innate immune reactions against microbial infection. TLRs also play essential roles …