PI3K/AKT pathway and its mediators in thyroid carcinomas
Z Nozhat, M Hedayati - Molecular diagnosis & therapy, 2016 - Springer
Thyroid malignancies are the most common endocrine system carcinomas, with four
histopathological forms. The phosphoinositide 3-kinase–protein kinase B/AKT (PI3K …
histopathological forms. The phosphoinositide 3-kinase–protein kinase B/AKT (PI3K …
The PI3K-Akt-mTOR pathway in initiation and progression of thyroid tumors
M Saji, MD Ringel - Molecular and cellular endocrinology, 2010 - Elsevier
The phosphoinositide-3 (OH) kinase (PI3K) signaling cascade is involved in regulating
glucose uptake and metabolism, growth, motility, and other essential functions for cell …
glucose uptake and metabolism, growth, motility, and other essential functions for cell …
PI3K/Akt/mTOR: A promising therapeutic target for non-medullary thyroid carcinoma
MS Petrulea, TS Plantinga, JW Smit… - Cancer treatment …, 2015 - Elsevier
Thyroid carcinoma (TC) is the most common endocrine malignancy. The pathogenesis of TC
is complex and involves multiple genetic events that lead to activation of oncogenic …
is complex and involves multiple genetic events that lead to activation of oncogenic …
Dysregulation of the phosphatidylinositol 3-kinase pathway in thyroid neoplasia
JE Paes, MD Ringel - Endocrinology and metabolism clinics of North …, 2008 - Elsevier
The phosphatidylinositol 3-kinase (PI3K) signaling pathway is an important regulator of
many cellular events, including apoptosis, proliferation, and motility. Enhanced activation of …
many cellular events, including apoptosis, proliferation, and motility. Enhanced activation of …
PI3K/Akt/mTOR signaling in medullary thyroid cancer: a promising molecular target for cancer therapy
GI Manfredi, A Dicitore, G Gaudenzi, M Caraglia… - Endocrine, 2015 - Springer
Abstract The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin
(mTOR) pathway is a central hub for the regulation of cell proliferation, apoptosis, cell cycle …
(mTOR) pathway is a central hub for the regulation of cell proliferation, apoptosis, cell cycle …
Genetic alterations in the phosphatidylinositol-3 kinase/Akt pathway in thyroid cancer
M Xing - Thyroid, 2010 - liebertpub.com
Background: Aberrant activation of the phosphatidylinositol-3 kinase (PI3K)/Akt pathway
plays a fundamental role in thyroid tumorigenesis, particularly in follicular thyroid cancer …
plays a fundamental role in thyroid tumorigenesis, particularly in follicular thyroid cancer …
FOXO3 is inhibited by oncogenic PI3K/Akt signaling but can be reactivated by the NSAID sulindac sulfide
C Weidinger, K Krause, K Mueller… - The Journal of …, 2011 - academic.oup.com
Background: Overactivation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway has
emerged as a pivotal trigger of thyroid carcinogenesis. Recent findings from other tumor …
emerged as a pivotal trigger of thyroid carcinogenesis. Recent findings from other tumor …
RETRACTED ARTICLE: The Akt inhibitor KP372-1 suppresses Akt activity and cell proliferation and induces apoptosis in thyroid cancer cells
M Mandal, S Kim, MN Younes, SA Jasser… - British journal of …, 2005 - nature.com
Abstract The phosphatidylinositol 3′ kinase (PI3K)/phosphatase and tensin homologue
deleted on chromosome ten/Akt pathway, which is a critical regulator of cell proliferation and …
deleted on chromosome ten/Akt pathway, which is a critical regulator of cell proliferation and …
Genetic alterations in the phosphoinositide 3-kinase/Akt signaling pathway confer sensitivity of thyroid cancer cells to therapeutic targeting of Akt and mammalian …
We investigated the genotype-dependent therapeutic potential of targeting the
phosphoinositide 3-kinase (PI3K)/Akt pathway for thyroid cancer. Proliferation of TPC1 …
phosphoinositide 3-kinase (PI3K)/Akt pathway for thyroid cancer. Proliferation of TPC1 …
Key signaling pathways in thyroid cancer
MA Zaballos, P Santisteban - Journal of Endocrinology, 2017 - joe.bioscientifica.com
Whole genome sequencing approaches have provided unprecedented insights into the
genetic lesions responsible for the onset, progression and dedifferentiation of various types …
genetic lesions responsible for the onset, progression and dedifferentiation of various types …
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