Thyroid malignancies are the most common endocrine system carcinomas, with four
histopathological forms. The phosphoinositide 3-kinase–protein kinase B/AKT (PI3K …

The phosphoinositide-3 (OH) kinase (PI3K) signaling cascade is involved in regulating
glucose uptake and metabolism, growth, motility, and other essential functions for cell …

Thyroid carcinoma (TC) is the most common endocrine malignancy. The pathogenesis of TC
is complex and involves multiple genetic events that lead to activation of oncogenic …

The phosphatidylinositol 3-kinase (PI3K) signaling pathway is an important regulator of
many cellular events, including apoptosis, proliferation, and motility. Enhanced activation of …

Abstract The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin
(mTOR) pathway is a central hub for the regulation of cell proliferation, apoptosis, cell cycle …

Background: Aberrant activation of the phosphatidylinositol-3 kinase (PI3K)/Akt pathway
plays a fundamental role in thyroid tumorigenesis, particularly in follicular thyroid cancer …

Background: Overactivation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway has
emerged as a pivotal trigger of thyroid carcinogenesis. Recent findings from other tumor …

Abstract The phosphatidylinositol 3′ kinase (PI3K)/phosphatase and tensin homologue
deleted on chromosome ten/Akt pathway, which is a critical regulator of cell proliferation and …

We investigated the genotype-dependent therapeutic potential of targeting the
phosphoinositide 3-kinase (PI3K)/Akt pathway for thyroid cancer. Proliferation of TPC1 …

Whole genome sequencing approaches have provided unprecedented insights into the
genetic lesions responsible for the onset, progression and dedifferentiation of various types …