Small Organic Compounds Enhance Antigen Loading of Class II Major Histocompatibility Complex Proteins by Targeting the Polymorphic P1 Pocket*♦
S Höpner, K Dickhaut, M Hofstätter… - Journal of biological …, 2006 - ASBMB
Major histocompatibility complex (MHC) molecules are a key element of the cellular immune
response. Encoded by the MHC they are a family of highly polymorphic peptide receptors …
response. Encoded by the MHC they are a family of highly polymorphic peptide receptors …
Binding interactions between peptides and proteins of the class II major histocompatibility complex
BJ McFarland, C Beeson - Medicinal research reviews, 2002 - Wiley Online Library
The activation of helper T cells by peptides bound to proteins of the class II Major
Histocompatibility Complex (MHC II) is pivotal to the initiation of an immune response. The …
Histocompatibility Complex (MHC II) is pivotal to the initiation of an immune response. The …
Ligand exchange of major histocompatibility complex class II proteins is triggered by H-bond donor groups of small molecules
K Falk, JM Lau, L Santambrogio, VM Esteban… - Journal of Biological …, 2002 - ASBMB
Hydrogen bonds (H-bonds) are crucial for the stability of the peptide-major histocompatibility
complex (MHC) complex. In particular, the H-bonds formed between the peptide ligand and …
complex (MHC) complex. In particular, the H-bonds formed between the peptide ligand and …
Cooperativity during the formation of peptide/MHC class II complexes
MW Anderson, J Gorski - Biochemistry, 2005 - ACS Publications
To generate an effective immune response, class II major histocompatibility complex
molecules (MHCII) must present a diverse array of peptide ligands for recognition by T …
molecules (MHCII) must present a diverse array of peptide ligands for recognition by T …
High-throughput engineering and analysis of peptide binding to class II MHC
Class II major histocompatibility complex (MHC-II) proteins govern stimulation of adaptive
immunity by presenting antigenic peptides to CD4+ T lymphocytes. Many allelic variants of …
immunity by presenting antigenic peptides to CD4+ T lymphocytes. Many allelic variants of …
Relative implication of peptide residues in binding to major histocompatibility complex class I H-2Db: application to the design of high-affinity, allele-specific peptides
D Hudrisier, H Mazarguil, MBA Oldstone… - Molecular immunology, 1995 - Elsevier
The H-2Db peptide sequence SMIENLEYM was manipulated (N-and C-terminus truncation
and alanine substitution) to determine the role of structural elements (peptide ends and …
and alanine substitution) to determine the role of structural elements (peptide ends and …
[HTML][HTML] The class II MHC protein HLA-DR1 in complex with an endogenous peptide: implications for the structural basis of the specificity of peptide binding
Background: Class II major histocompatibility complex (MHC) proteins are cell surface
glycoproteins that bind peptides and present them to T cells as part of the mechanism for …
glycoproteins that bind peptides and present them to T cells as part of the mechanism for …
A tricyclic ring system replaces the variable regions of peptides presented by three alleles of human MHC class I molecules
GA Weiss, EJ Collins, DN Garboczi, DC Wiley… - Chemistry & biology, 1995 - cell.com
Background: Cytotoxic T-lymphocytes (CTLs) recognize complexes of short peptides with
major histocompatibility complex (MHC) class I molecules. MHC molecules are polymorphic …
major histocompatibility complex (MHC) class I molecules. MHC molecules are polymorphic …
[HTML][HTML] Tolerance to amino acid variations in peptides binding to the major histocompatibility complex class I protein H-2Kb
K Udaka, KH Wiesmüller, S Kienle, G Jung… - Journal of Biological …, 1995 - Elsevier
Major histocompatibility complex (MHC) class I molecules are cell-surface glycoproteins that
bind peptides and present them to T cells. The formation of a peptide-MHC complex is the …
bind peptides and present them to T cells. The formation of a peptide-MHC complex is the …
N‐terminal elongation of a peptide determinant beyond the first primary anchor improves binding to H‐2 I‐Ad and HLA‐DR1 by backbone‐dependent and aromatic …
K Bartnes, F Leon, JP Briand, PJ Travers… - European journal of …, 1999 - Wiley Online Library
The IgG2ab heavy chain allopeptide determinant γ2ab 436–451 (Kabat numbering)
presented by the major histocompatibility complex (MHC) class II molecule I‐Ad is …
presented by the major histocompatibility complex (MHC) class II molecule I‐Ad is …