Soluble fibrin is observed in patients with intravascular coagulation and represents an
intermediary product of conversion of fibrin monomers into a fibrin clot whereby the …

During the transformation of fibrinogen to fibrin, excess fibrinogen suppresses further
polymerization of fibrin, thereby enabling the nascent fibrin to be transported in a soluble …

The fibrin polymers formed in solution during the earliest phase of the fibrinogen–fibrin
conversion are shown to be stable soluble molecules at pH7. 4 and 0.15 m-or 0.3 m-NaCl …

The process of fibrin formation using highly purified fibrinogen and thrombin was studied
using laser fluctuation spectroscopy, a method that rapidly determines particle size in a …

Incubation of fibrinogen with small amounts of thrombin resulted in the occurrence of soluble
fibrin monomer complexes. These complexes consisted predominantly of a derivative with a …

Soluble oligomers of fibrin were produced by limited incubation of fibrinogen with thrombin
in the presence of calcium2®, cysteine and factor XIII. They were separated from fibrinogen …

D. Knoll, 1 R. Hantgan,® J. Williams, 11J. McDonagh, 1 and J. Hermans* abstract:
Polymerization of fibrin is inhibited in the presence of excess fibrinogen fragment D. This …

The binding between complementary polymerization sites of fibrin monomers plays an
essential role in the formation of the fibrin clot. One set of polymerization sites involved in the …

Soluble fibrin oligomers were formed by reacting fibrinogen with thrombin under fine clotting
conditions where the action of thrombin is the rate‐determining step for polymerization, and …

Fibrin polymerization begins with the thrombin-catalyzed cleavage of fibrinopeptides from
fibrinogen and proceeds through several assembly steps to form an insoluble fibrin clot …