Neuroinflammation in cerebral ischemia and ischemia/reperfusion injuries: from pathophysiology to therapeutic strategies

A Jurcau, A Simion - International journal of molecular sciences, 2021 - mdpi.com
Its increasing incidence has led stroke to be the second leading cause of death worldwide.
Despite significant advances in recanalization strategies, patients are still at risk for …

Neuroinflammation: friend and foe for ischemic stroke

RL Jayaraj, S Azimullah, R Beiram, FY Jalal… - Journal of …, 2019 - Springer
Stroke, the third leading cause of death and disability worldwide, is undergoing a change in
perspective with the emergence of new ideas on neurodegeneration. The concept that …

Inflammation in ischemic stroke: mechanisms, consequences and possible drug targets

M Ahmad, NJ Dar, ZS Bhat, A Hussain… - CNS & Neurological …, 2014 - ingentaconnect.com
Ischemic stroke is caused when blood flow to the brain is hampered, leading to instant
deficiency of nutrients and oxygen required for normal brain functioning. Reperfusion can …

Neuroinflammation in acute ischemic and hemorrhagic stroke

DL Alsbrook, M Di Napoli, K Bhatia, J Biller… - Current neurology and …, 2023 - Springer
Abstract Purpose of Review This review aims to provide an overview of neuroinflammation
in ischemic and hemorrhagic stroke, including recent findings on the mechanisms and …

Neuroinflammation as a key driver of secondary neurodegeneration following stroke?

SM Stuckey, LK Ong, LE Collins-Praino… - International Journal of …, 2021 - mdpi.com
Ischaemic stroke involves the rapid onset of focal neurological dysfunction, most commonly
due to an arterial blockage in a specific region of the brain. Stroke is a leading cause of …

Inflammation after stroke: mechanisms and therapeutic approaches

M Ahmad, SH Graham - Translational stroke research, 2010 - Springer
Reperfusion of ischemic brain can reduce injury and improve outcome, but secondary injury
due to inflammatory mechanisms limits the efficacy and time window of such treatments for …

Neuroinflammation in post-ischemic neurodegeneration of the brain: friend, foe, or both?

R Pluta, S Januszewski, SJ Czuczwar - International Journal of Molecular …, 2021 - mdpi.com
One of the leading causes of neurological mortality, disability, and dementia worldwide is
cerebral ischemia. Among the many pathological phenomena, the immune system plays an …

Innate inflammatory responses in stroke: mechanisms and potential therapeutic targets

JY Kim, M Kawabori, MA Yenari - Current medicinal chemistry, 2014 - ingentaconnect.com
Stroke is a frequent cause of long-term disability and death worldwide. Ischemic stroke is
more commonly encountered compared to hemorrhagic stroke, and leads to tissue death by …

Inflammation, plasticity and real-time imaging after cerebral ischemia

J Kriz, M Lalancette-Hébert - Acta neuropathologica, 2009 - Springer
With an incidence of approximately 350 in 100,000, stroke is the third leading cause of death
and a major cause of disability in industrialized countries. At present, although progress has …

Inflammation and neural repair after ischemic brain injury

S Sakai, T Shichita - Neurochemistry International, 2019 - Elsevier
Stroke causes neuronal cell death and destruction of neuronal circuits in the brain and
spinal cord. Injury to the brain tissue induces sterile inflammation triggered by the …