The unique redox potential of iron makes it an ideal cofactor in diverse biochemical
reactions. Iron is therefore vital for the growth and proliferation of nearly all organisms …

Staphylococcus aureus pathogenesis is significantly influenced by the iron status of the host.
However, the regulatory impact of host iron sources on S. aureus gene expression remains …

The use of iron as an enzymatic cofactor is pervasive in biological systems. Consequently
most living organisms, including pathogenic bacteria, require iron to survive and replicate …

Iron is frequently a growth-limiting nutrient due to its propensity to interact with oxygen to
form insoluble precipitates and, therefore, biological systems have evolved specialized …

Pathogenic Gram-positive bacteria encounter many obstacles in route to successful invasion
and subversion of a mammalian host. As such, bacterial species have evolved clever ways …

Staphylococcus aureus is a versatile opportunistic human pathogen. Infection by this
bacterium requires uptake of iron from the human host, but iron is highly restricted in this …

Nutritional immunity is a form of innate immunity widespread in both vertebrates and
invertebrates. The term refers to a rich repertoire of mechanisms set up by the host to inhibit …

Molecular determinants underlying the production of siderophores in the human and animal
pathogen Staphylococcus aureus and the contribution of siderophore production to the …

Iron acquisition is a vital process for most pathogenic bacteria, as iron is a limiting nutrient
during infection. Staphylococcus aureus, an increasingly important pathogen, acquires iron …

The tremendous success of Staphylococcus aureus as a pathogen is due to the controlled
expression of a diverse array of virulence factors. The effects of host environments on the …