Serotonin 5-HT7 receptor agents: structure-activity relationships and potential therapeutic applications in central nervous system disorders

M Leopoldo, E Lacivita, F Berardi, R Perrone… - Pharmacology & …, 2011 - Elsevier
Since its discovery in the 1940s in serum, the mammalian intestinal mucosa, and in the
central nervous system, serotonin (5-HT) has been shown to be involved in virtually all …

Direct Immunohistochemical Evidence of the Existence of 5‐HT1A Autoreceptors on Serotoninergic Neurons in the Midbrain Raphe Nuclei

C Sotelo, B Cholley, S El Mestikawy… - European Journal of …, 1990 - Wiley Online Library
Physiological, pharmacological and radioautographic binding studies have suggested the
presence of the 5‐HT1A autoreceptors on midbrain serotoninergic neurons. The recent …

Cloning and characterization of a novel human 5-HT4 receptor variant that lacks the alternatively spliced carboxy terminal exon. RT-PCR distribution in human brain …

MT Vilaró, T Doménech, JM Palacios, G Mengod - Neuropharmacology, 2002 - Elsevier
We have cloned a novel C-terminal splice variant of serotonin 5-HT4 receptors from human
hippocampus. The deduced protein extends only one aminoacid past the splicing point. We …

Pontomedullary distribution of 5‐HT2A receptor‐like protein in the rat

R Fay, L Kubin - Journal of Comparative Neurology, 2000 - Wiley Online Library
Abstract Serotonin (5‐HT) exerts excitatory effects in many brainstem regions involved in
autonomic, somatic, motor, and sensory functions, and in control of vigilance. To determine …

Cloning and characterisation of the human 5‐HT5A serotonin receptor

S Rees, I den Daas, S Foord, S Goodson, D Bull… - FEBS …, 1994 - Wiley Online Library
The human 5‐HT5A serotonin receptor has been cloned. As with the mouse and rat 5‐HT5A
receptors, the gene consists of two coding exons separated by a large intron. The deduced …

Light and electron microscopic immunocytochemical visualization of 5-HT1B receptors in the rat brain

Y Sari, K Lefèvre, M Bancila, M Quignon, MC Miquel… - Brain research, 1997 - Elsevier
Specific antipeptide antibodies were used for the immunohistochemical visualization of 5-
HT1B receptors in the rat brain. A dense, specific 5-HT1B receptor-like immunoreactivity was …

Detailed mapping of serotonin 5-HT1B and 5-HT1D receptor messenger RNA and ligand binding sites in guinea-pig brain and trigeminal ganglion: clues for function

P Bonaventure, P Voorn, W Luyten, M Jurzak… - Neuroscience, 1997 - Elsevier
The similar pharmacology of the 5-HT1B and 5-HT1D receptors, and the lack of selective
compounds sufficiently distinguishing between the two receptor subtypes, have hampered …

Central distribution and function of 5-HT6 receptor subtype in the rat brain

M Yoshioka, M Matsumoto, H Togashi, K Mori, H Saito - Life sciences, 1998 - Elsevier
The purpose of the present study was to elucidate the distribution of 5-HT6 receptor mRNA
and possible physiological functions of the 5-HT6 receptor subtype using antisense …

Regional distribution and cellular localization of 5‐HT2C receptor mRNA in monkey brain: Comparison with [3H]mesulergine binding sites and choline …

JF López‐Giménez, G Mengod, JM Palacios… - Synapse, 2001 - Wiley Online Library
The distribution of serotonin 5‐HT2C receptor mRNA in monkey brain was studied by in situ
hybridization and compared with the distribution of [3H] mesulergine binding sites as …

Distribution and cellular localization of mRNA coding for 5-HT1A receptor in the rat brain: correlation with receptor binding

M Pompeiano, JM Palacios… - Journal of Neuroscience, 1992 - Soc Neuroscience
In order to localize the cells expressing 5-HT1A receptors in the rat brain, we used in situ
hybridization histochemistry to visualize the distribution of the mRNA coding for 5-HT1A …