The human 5-HT 6 receptor (5-HT 6 R) is one of the latest cloned receptors among the
known 5-HT receptors. Its abundant distribution in the limbic region, which participates in the …

Abstract Functional serotonin (5-hydroxytryptamine, 5-HT) receptors have been divided into
three subtypes: 5-HT1,-like, 5-HT2 and 5-HT3,(ref. 1). Brain binding sites have been …

Like most neurotransmitters, serotonin possesses a simple structure. However, the
pharmacological consequences are more complex and diverse. Serotonin is involved in …

5-HT4 receptors mediate several physiological effects of 5-HT, particularly in the central
nervous system (CNS), heart and gut. Recently, several C-terminal splice variants of the …

The distribution of serotonin-1 (5-HT 1) receptors in the rat brain was studied by light
microscopic quantitative autoradiography. Receptors were labeled with [3 H] serotonin (5-[3 …

The mouse 5-HT2C receptor and its third and fourth (C-terminal) cytoplasmic domain have
been expressed as fusion proteins in bacteria. After purification antisera were generated …

Introduction. The human 5-HT7 receptor is a recently discovered member of the seven-
transmembrane G-protein-coupled receptor superfamily. 2 The most abundant isoform 5 …

The ability of differing subunit combinations of 5-HT3 receptors to form functional cell surface
receptors was analyzed by a variety of approaches. The results revealed that 5-HT3 receptor …

The 5-HT1 receptor family comprises five different pharmacologic subtypes, designated 5-
HT1A, 5-HT1B, 5-HT1C, 5-HT1D, and 5-HT1E, whose common property is to bind 5-HT with …

Abstract The 5‐hydroxytryptamine (5‐HT4) receptor may be implicated in depression and is
a new potential target for antidepressant treatment. We have investigated the brain 5‐HT4 …