Real-world experience with targeted therapy for the treatment of anaplastic thyroid carcinoma
Background: Patients with anaplastic thyroid cancer (ATC) have a dismal prognosis, despite
systemic cytotoxic chemotherapy. The objective of this study was to investigate the efficacy …
systemic cytotoxic chemotherapy. The objective of this study was to investigate the efficacy …
Mutation based approaches to the treatment of anaplastic thyroid cancer
HC McCrary, J Aoki, Y Huang, B Chadwick… - Clinical …, 2022 - Wiley Online Library
Objective The treatment of anaplastic thyroid cancer (ATC) has continued to rapidly evolve
over time. Increased utilization of novel, personalized therapies based upon the tumour's …
over time. Increased utilization of novel, personalized therapies based upon the tumour's …
Dabrafenib and trametinib therapy for advanced anaplastic thyroid cancer–real-world outcomes from UK centres
C Lorimer, L Cheng, R Chandler, K Garcez, V Gill… - Clinical Oncology, 2023 - Elsevier
Aims Anaplastic thyroid cancer (ATC) is a rare but aggressive form of thyroid cancer with a
median survival of 4 months. Recent advances in molecular profiling have shown that up to …
median survival of 4 months. Recent advances in molecular profiling have shown that up to …
A systematic review of phase II targeted therapy clinical trials in anaplastic thyroid cancer
J Ljubas, T Ovesen, M Rusan - Cancers, 2019 - mdpi.com
Anaplastic thyroid carcinoma (ATC) is a rare, but devastating disease. Despite multimodal
approaches combining surgery, chemotherapy and radiation therapy, ATC is associated …
approaches combining surgery, chemotherapy and radiation therapy, ATC is associated …
Advances in the management of anaplastic thyroid carcinoma: transforming a life-threatening condition into a potentially treatable disease
I Califano, A Smulever, F Jerkovich, F Pitoia - Reviews in Endocrine and …, 2024 - Springer
Anaplastic thyroid cancer (ATC) is an infrequent thyroid tumor that usually occurs in elderly
patients. There is often a history of previous differentiated thyroid cancer suggesting a …
patients. There is often a history of previous differentiated thyroid cancer suggesting a …
Open-label, single-arm, multicenter, phase II trial of lenvatinib for the treatment of patients with anaplastic thyroid cancer
LJ Wirth, MS Brose, EJ Sherman, L Licitra… - Journal of Clinical …, 2021 - ascopubs.org
PURPOSE Anaplastic thyroid cancer (ATC), an aggressive malignancy, is associated with a
poor prognosis and an unmet need for effective treatment, especially for patients without …
poor prognosis and an unmet need for effective treatment, especially for patients without …
[HTML][HTML] Phase II study of the efficacy and safety of lenvatinib for anaplastic thyroid cancer (HOPE)
T Higashiyama, K Sugino, H Hara, K Ito… - European Journal of …, 2022 - Elsevier
Purpose Anaplastic thyroid cancer (ATC) is a rare and highly aggressive cancer for which
effective systemic therapy has long been sought. Here, we assessed the efficacy and safety …
effective systemic therapy has long been sought. Here, we assessed the efficacy and safety …
Multimodal treatments and outcomes for anaplastic thyroid cancer before and after tyrosine kinase inhibitor therapy: a real-world experience
Background Anaplastic thyroid cancer (ATC) has dismal prognosis and there is no effective
treatment. We aimed to evaluate the efficacy of tyrosine kinase inhibitor (TKI) therapy in real …
treatment. We aimed to evaluate the efficacy of tyrosine kinase inhibitor (TKI) therapy in real …
Targeted therapy for anaplastic thyroid carcinoma: advances and management
J Yuan, Y Guo - Cancers, 2022 - mdpi.com
Simple Summary The exceedingly aggressive and rare tumor, anaplastic thyroid carcinoma,
is generally resistant to traditional antitumor therapies. In recent years, targeted therapy has …
is generally resistant to traditional antitumor therapies. In recent years, targeted therapy has …
Recent advances in the management of anaplastic thyroid cancer
S De Leo, M Trevisan, L Fugazzola - Thyroid research, 2020 - Springer
Anaplastic thyroid cancer (ATC) is undoubtedly the thyroid cancer histotype with the poorest
prognosis. The conventional treatment includes surgery, radiotherapy, and conventional …
prognosis. The conventional treatment includes surgery, radiotherapy, and conventional …