Oxidative stress is a reflection of the imbalance between the production of reactive oxygen
species (ROS) and the scavenging capacity of the antioxidant system. Excessive ROS …

Liver fibrosis represents a health problem with significant morbidity and mortality that affects
100 million people worldwide. It is a final pathway to several chronic liver diseases and is …

The liver can succumb to oxidant damage during the development of chronic liver diseases.
Despite their physiological relevance to hepatic homeostasis, excessive reactive …

Liver disease is a highly prevalent disease that is one of the leading causes of death
worldwide. The continuous exposure of the liver to some factors such as viruses, alcohol, fat …

Reactive oxygen species-(ROS-) induced oxidative stress has been implicated in various
forms of diseases. Excessive ROS generation depletes the endogenous antioxidants that …

Oxygen is vital for life as it is required for many different enzymatic reactions involved in
intermediate metabolism and xenobiotic biotransformation. Moreover, oxygen consumption …

Liver fibrosis is the pathological consequence of chronic liver diseases, where an excessive
deposition of extracellular matrix (ECM) proteins occurs, concomitantly with the processes of …

Activated hepatic stellate cells (HSCs) and myofibroblasts are the main producers of
extracellular matrix (ECM) proteins that form the fibrotic tissue that leads to hepatic fibrosis …

In physiology, reactive oxygen species (ROS) are produced by most cells for normal function
and as a defense mechanism against foreign particles, microbes and viruses. Hepatic …

The liver is an organ that is particularly exposed to reactive oxygen species (ROS), which
not only arise during metabolic functions but also during the biotransformation of …