Putative chanzyme activity of TRPM2 cation channel is unrelated to pore gating

B Tóth, I Iordanov, L Csanády - Proceedings of the National …, 2014 - National Acad Sciences
Transient receptor potential melastatin 2 (TRPM2) is a Ca2+-permeable cation channel
expressed in immune cells of phagocytic lineage, pancreatic β cells, and brain neurons and …

Trpm2

M Faouzi, R Penner - … Transient Receptor Potential (TRP) Cation Channels …, 2014 - Springer
TRPM2 is the second member of the transient receptor potential melastatin-related (TRPM)
family of cation channels. The protein is widely expressed including in the brain, immune …

The proposed channel-enzyme transient receptor potential melastatin 2 does not possess ADP ribose hydrolase activity

I Iordanov, C Mihalyi, B Toth, L Csanady - Elife, 2016 - elifesciences.org
Transient Receptor Potential Melastatin 2 (TRPM2) is a Ca2+-permeable cation channel
essential for immunocyte activation, insulin secretion, and postischemic cell death. TRPM2 …

[HTML][HTML] Selective profiling of N-and C-terminal nucleotide-binding sites in a TRPM2 channel

B Tóth, I Iordanov, L Csanády - Journal of General Physiology, 2020 - rupress.org
Transient receptor potential melastatin 2 (TRPM2) is a homotetrameric Ca 2+-permeable
cation channel important for the immune response, body temperature regulation, and insulin …

The selectivity filter of the cation channel TRPM4

B Nilius, J Prenen, A Janssens, G Owsianik… - Journal of Biological …, 2005 - ASBMB
Transient receptor potential channel melastatin subfamily (TRPM) 4 and its close
homologue, TRPM5, are the only two members of the large transient receptor potential …

Pore collapse underlies irreversible inactivation of TRPM2 cation channel currents

B Tóth, L Csanády - … of the National Academy of Sciences, 2012 - National Acad Sciences
The Ca2+-permeable cation channel transient receptor potential melastatin 2 (TRPM2)
plays a key role in pathogen-evoked phagocyte activation, postischemic neuronal apoptosis …

State-dependent inhibition of TRPM2 channel by acidic pH

W Yang, J Zou, R Xia, ML Vaal, VA Seymour… - Journal of Biological …, 2010 - ASBMB
Transient receptor potential melastatin 2 (TRPM2) channel fulfills an important role in
oxidative stress signaling in immune and other cells, to which local extracellular acidosis is …

TRPM2: a multifunctional ion channel for calcium signalling

A Sumoza‐Toledo, R Penner - The Journal of physiology, 2011 - Wiley Online Library
The transient potential receptor melastatin‐2 (TRPM2) channel has emerged as an
important Ca2+ signalling mechanism in a variety of cells, contributing to cellular functions …

Ligand-induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg1433 and Tyr1349

R Fliegert, JM Watt, A Schöbel, MD Rozewitz… - Biochemical …, 2017 - portlandpress.com
TRPM2 (transient receptor potential channel, subfamily melastatin, member 2) is a Ca2+-
permeable non-selective cation channel activated by the binding of adenosine 5 …

Identification of direct and indirect effectors of the transient receptor potential melastatin 2 (TRPM2) cation channel

B Tóth, L Csanády - Journal of Biological Chemistry, 2010 - ASBMB
Transient receptor potential melastatin 2 (TRPM2) is a Ca 2+-permeable cation channel
involved in physiological and pathophysiological processes linked to oxidative stress …