In response to myocardial infarction (MI), the wound healing response of the left ventricle
(LV) comprises overlapping inflammatory, proliferative, and maturation phases, and the …

Cardiac fibroblasts (CF) play a pivotal role in the repair and remodeling of the heart that
occur following myocardial infarction (MI). The transition through the inflammatory …

Fibroblasts do not only serve as matrix-producing reparative cells, but exhibit a wide range
of functions in inflammatory and immune responses, angiogenesis and neoplasia. The adult …

Cardiac wound healing after myocardial infarction (MI) evolves from pro-inflammatory to anti-
inflammatory to reparative responses, and the cardiac fibroblast is a central player during …

Fibroblasts are the predominant cell type in the cardiac interstitium. As the main matrix-
producing cells in the adult mammalian heart, fibroblasts maintain the integrity of the …

The adult mammalian heart contains abundant interstitial and perivascular fibroblasts that
expand following injury and play a reparative role but also contribute to maladaptive fibrotic …

Cardiac fibroblasts are key cellular effectors of cardiac repair; their phenotype and function
are modulated by interactions with extracellular matrix proteins. This review manuscript …

Inflammatory and fibrotic responses to myocardial damage are essential for cardiac repair;
however, these responses often result in extensive fibrotic remodeling with impaired systolic …

Pathological changes resulting from myocardial infarction (MI) include extracellular matrix
alterations of the left ventricle, which can lead to cardiac stiffness and impair systolic and …

Expansion and activation of fibroblasts following cardiac injury is important for repair but
may also contribute to fibrosis, remodeling, and dysfunction. The authors discuss the …