Objective: Treatment with recombinant interferon is associated with high rates of psychiatric
comorbidity. We investigated the relation between catabolism of the essential amino acid …

Background Interferon-alpha (IFN α)-associated mood disorder is a major complication of
treatment for chronic hepatitis C. Method The authors report on three patients infected with …

Aims: Depression and other psychiatric disorders are frequent in HCV-infected patients,
especially during interferon treatment. The molecular mechanism (s) maderlying this finding …

Method Patients. Ten patients (mean [SD] age 45 years [12.7], range 29-63; three males,
seven females) with chronic hepatitis C eligible to receive IFN-alpha (1.5 microg/kg/week …

There is now evidence that repeated administration of interferon-α (IFN-α) to patients with
chronic active hepatitis and cancers induces depressive symptoms. There is also evidence …

Abstract Background: Interferon-α (IFN-α) treatment is often associated with psychiatric side
effects and has been found to lower the amount of tryptophan (TRP) available to the brain …

Depression is a common side-effect of interferon (IFN)-alpha treatment of hepatitis C virus
(HCV) infection and melanoma. Disturbances of tryptophan (TRP) metabolism might …

BACKGROUND.: Interferon-induced depression ranges from 0 to 50%. Interferon schedule
and a history of psychiatric illnesses are not enough to predict who will develop symptoms …

The currently recommended therapy for chronic hepatitis C (HCV) is a combination of
pegylated interferon-alpha (PEG-IFN alpha) and ribavirin. Psychiatric disorders, including …

Immunotherapy with interferons may induce neuropsychiatric symptoms and disorders.
Interferon-α-based immunotherapy is used to treat patients with chronic hepatitis C and …