Bone morphogenetic proteins (BMPs) and Wnts are important signaling protein families with
key roles in embryologic, patterning, development, and tissue remodeling in growth. BMP …

Functional genomics is a challenging new way to address a complex disease like
osteoarthritis on a molecular level. Despite osteoarthritis being ultimately a biochemical …

Osteoarthritis (OA) affects 7% of global population, over 500 million people worldwide. It is a
leading cause of chronic pain and disability in older adults. OA not only affects large joints in …

Osteoarthritis (OA) is a common disease characterized by cartilage degeneration and joint
remodeling. The underlying molecular changes underpinning disease progression are …

Articular cartilage (AC) covers the diarthrodial joints and is responsible for the mechanical
distribution of loads across the joints. The majority of its structure and function is controlled …

Bone is a mineralized and elastic connective tissue that provides fundamental functions in
the human body, including mechanical support to the muscles and joints, protection of vital …

Vascular‐invasion‐mediated interactions between activated articular chondrocytes and
subchondral bone are essential for osteoarthritis (OA) development. Here, we determined …

Osteoporotic osteoarthritis (OPOA) is a common bone disease mostly in the elderly, but the
relationship between OP and OA is complex. It has been shown that knee loading can …

There is emerging awareness that subchondral bone remodeling plays an important role in
the development of osteoarthritis (OA). This review presents recent investigations on the …

Osteoarthritis (OA) is a painful and disabling disease that affects millions of patients. Its
etiology is largely unknown, but it is most likely multifactorial. OA pathogenesis involves the …