[PDF][PDF] Handling the Hurdles on the Way to Anti-tuberculosis Drug Development

CV Bizarro, EV de Souza, BL Abbadi… - Frontiers in …, 2020 - repositorio.pucrs.br
Human tuberculosis (TB), mainly caused by the bacterial pathogen Mycobacterium
tuberculosis, is a chronic, infectious-contagious, and deadly disease that has reached …

[HTML][HTML] Handling the hurdles on the way to anti-tuberculosis drug development

PF Dalberto, EV De Souza, BL Abbadi… - Frontiers in …, 2020 - frontiersin.org
The global epidemic of tuberculosis (TB) imposes a sustained epidemiologic vigilance and
investments in research by governments. Mycobacterium tuberculosis, the main causative …

Tuberculosis drug discovery: challenges and new horizons

GFS Fernandes, AM Thompson… - Journal of Medicinal …, 2022 - ACS Publications
Over the past 2000 years, tuberculosis (TB) has claimed more lives than any other infectious
disease. In 2020 alone, TB was responsible for 1.5 million deaths worldwide, comparable to …

Current status and research strategies in tuberculosis drug development: miniperspective

LG Dover, GD Coxon - Journal of medicinal Chemistry, 2011 - ACS Publications
In this Miniperspective we broadly cover the recent developments and strategies that are
being adopted globally in the battle to urgently discover and develop new drugs to treat …

Improving the tuberculosis drug development pipeline

D Evangelopoulos, TD McHugh - Chemical Biology & Drug …, 2015 - Wiley Online Library
Mycobacterium tuberculosis is considered one of the most successful pathogens and
multidrug‐resistant tuberculosis, a disease that urgently requires new chemical entities to be …

[PDF][PDF] DRUG DEVELOPMENT FOR TUBERCULOSIS: DESIGN AND

SM Hopfner - 2022 - scholarworks.montana.edu
Tuberculosis (TB) is a public health threat. According to the World Health Organization
(WHO) 2020 Global Tuberculosis report, over 10 million people became ill and 1.4 million …

Harnessing biological insight to accelerate tuberculosis drug discovery

TJ de Wet, DF Warner, V Mizrahi - Accounts of Chemical Research, 2019 - ACS Publications
Conspectus Tuberculosis (TB) is the leading cause of mortality globally resulting from an
infectious disease, killing almost 1.6 million people annually and accounting for …

[HTML][HTML] Tuberculosis Drug Discovery & Development: Drug Targets, Chemical Matter, and Approaches

V Singh - Frontiers in Cellular and Infection Microbiology, 2021 - frontiersin.org
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is the leading cause of
death from a single infectious agent ranking it above all other contagious diseases. About …

Drug discovery for TB: frontiers and perspectives

LB Marino, M Miyata, PC Souza… - Frontiers in Anti …, 2013 - books.google.com
Despite advances in the treatment of tuberculosis (TB) and increased effort to discover new
anti-TB drugs, 8.6 million people were affected by Mycobacterium tuberculosis infection …

Current Approaches to Tuberculosis Drug Discovery and Development

MJ Mitton-Fry, D Hanna - 2011 - books.rsc.org
Tuberculosis (TB) remains a dominant infectious disease causing morbidity and mortality
worldwide. 1, 2 It is estimated that one-third of the world's population is latently infected with …