At the end of the19th century, sleeping sickness decimated the populations of vast areas in
the Equatoria region of Southern Sudan (Kuzoe, 1991). The devastating epidemic in …

Background Individuals genetically susceptible to high schistosomiasis worm burden may
contribute disproportionately to transmission and could be prioritized for control. Identifying …

Over the past decade, an increasing number of studies have demonstrated correlations
between host genetics and susceptibility to diseases. However, few studies have …

Although studies on African Trypanosomiases revealed a variety of trypanosome species in
the blood of various animal taxa, animal reservoirs of Trypanosoma brucei gambiense and …

Background Interferon-gamma is a key cytokine in the protective responses against
intracellular pathogens. A single nucleotide polymorphism (SNP) located in the first intron of …

Background Diverse clinical features have been reported in human African trypanosomiasis
(HAT) foci caused by Trypanosoma brucei rhodesiense (Tb rhodesiense) giving rise to the …

Pro-inflammatory cytokines IFNγ and IFNα function through their cellular receptors IFNγR1
and IFNαR1, respectively to mediate immune processes during malaria infection. A total of …

This study was designed to investigate the factors responsible for the persistence of
sleeping sickness in southeastern Uganda. In addition to the general aspects, this …

The history of human sleeping sickness in East Africa is characterized by the appearance of
disease epidemics interspersed by long periods of endemicity. Despite the presence of the …

Background Sleeping sickness caused by Trypanosoma brucei rhodesiense is a fatal
disease and endemic in Southern and Eastern Africa. There is an urgent need to develop …