Osteoarthritis (OA) has been recognized as the most common chronic age-related disease.
Cartilage degeneration influences OA therapy. Here we report that hematopoietic pre-B cell …

Stem cells remain in a quiescent state for long-term maintenance and preservation of
potency; this process requires fine-tuning regulatory mechanisms. In this study, we identified …

We previously reported a loss-of-PITX1 expression in patients suffering of knee/hip
osteoarthritis (OA). Search for the mechanism underlying this event led us to discover that …

Bone plays a role in energy metabolism, but the interplay between bone and other organs in
this process is not completely understood. Here, we show that upregulated Hh signaling in …

Background Although transition from proliferation to hypertrophic differentiation of
chondrocytes is a crucial step for endochondral ossification in physiological skeletal growth …

Osteoarthritis (OA) is an age-related disease, characterized by cartilage degeneration. The
pathogenesis of OA is complicated and the current therapeutic approaches for OA are …

Cellular senescence is a driver of various aging-associated disorders, including
osteoarthritis. Here, we identified a critical role for Yes-associated protein (YAP), a major …

The maintenance of regulatory T (Treg) cells critically prevents autoimmunity. Pre–B cell
leukemia transcription factor 1 (Pbx1) variants are associated with lupus susceptibility …

Background The cartilage stem/progenitor cells (CSPC) play a critical role in maintaining
cartilage homeostasis. However, the effects of phenotypic fluctuations of CSPC on cartilage …

Chondrocyte hypertrophy is an essential process required for endochondral bone formation.
Proper regulation of chondrocyte hypertrophy is also required in postnatal cartilage …