Airway and systemic oxidant-antioxidant dysregulation in asthma: a possible scenario of oxidants spill over from lung into blood

A Nadeem, N Siddiqui, NO Alharbi… - Pulmonary pharmacology …, 2014 - Elsevier
Asthma is characterized by repeated episodes of airway obstruction and an ongoing cycle of
airway inflammation. Reactive oxygen species (ROS) produced by inflammatory cells in the …

Oxidant—antioxidant imbalance in asthma: scientific evidence, epidemiological data and possible therapeutic options

A Nadeem, A Masood… - Therapeutic advances in …, 2008 - journals.sagepub.com
Prevalence of asthma has increased considerably in recent decades throughout the world
especially in developed countries. Airway inflammation is thought to be prime cause for …

Molecular mechanisms of oxidative stress in asthma

C Michaeloudes, H Abubakar-Waziri, R Lakhdar… - Molecular aspects of …, 2022 - Elsevier
The lungs are exposed to reactive oxygen species oxygen (ROS) produced as a result of
inhalation of oxygen, as well as smoke and other air pollutants. Cell metabolism and the …

Role of oxygen radicals on bronchial asthma

T Fujisawa - Current drug targets-Inflammation & allergy, 2005 - ingentaconnect.com
Bronchial asthma is an inflammatory disorder characterized by recruitment and activation of
various inflammatory cells including eosinophils and T cells in the airway mucosa. Oxygen …

Reactive oxygen species as mediators in asthma

PAJ Henricks, FP Nijkamp - Pulmonary pharmacology & therapeutics, 2001 - Elsevier
This review describes production and effects of reactive oxygen species (ROS) on airway
function. ROS are important in many physiological processes but can also have detrimental …

Oxidative stress in the pathogenesis of asthma

RP Bowler - Current allergy and asthma reports, 2004 - Springer
Abstract Asthma affects 5% to 10% of the population of the United States. In asthmatics,
oxidative stress occurs not only as a result of inflammation but also from environmental …

Importance of oxidative stress in the pathogenesis and treatment of asthma

MA Riedl, AE Nel - Current opinion in allergy and clinical …, 2008 - journals.lww.com
Our current understanding of the role of oxidative stress in asthma suggests that antioxidant
therapy may be important in optimizing asthma treatment and prevention. The future success …

Glutathione redox control of asthma: from molecular mechanisms to therapeutic opportunities

AM Fitzpatrick, DP Jones, LAS Brown - Antioxidants & redox …, 2012 - liebertpub.com
Asthma is a chronic inflammatory disorder of the airways associated with airway hyper-
responsiveness and airflow limitation in response to specific triggers. Whereas inflammation …

Oxidative stress in asthma and COPD: antioxidants as a therapeutic strategy

P Kirkham, I Rahman - Pharmacology & therapeutics, 2006 - Elsevier
Asthma and chronic obstructive pulmonary disease (COPD) are inflammatory lung diseases
that are characterized by systemic and chronic localized inflammation and oxidative stress …

Uncovering the role of oxidative imbalance in the development and progression of bronchial asthma

LHC Vasconcelos, SRD Ferreira… - Oxidative Medicine …, 2021 - Wiley Online Library
Asthma is a chronic inflammatory disease of the airways related to epithelial damage,
bronchial hyperresponsiveness to contractile agents, tissue remodeling, and luminal …