The 'glymphatic'system is a brain-wide network of perivascular pathways that supports
exchange of cerebrospinal fluid (CSF) and brain interstitial fluid (ISF), contributing to the …

The water channel aquaporin-4 (AQP4) is heavily enriched at glial barriers in the CNS,
including at the glia limitans, the basolateral membrane of ependymocytes, and the …

The glymphatic system is a brain-wide clearance pathway; its impairment contributes to the
accumulation of amyloid-β. Influx of cerebrospinal fluid (CSF) depends upon the expression …

Neurovascular pathology concurs with protein accumulation, as the brain vasculature is
important for waste clearance. Interstitial solutes, such as amyloid-β, were previously …

The glymphatic system is a brain-wide perivascular pathway driven by aquaporin-4 on the
endfeet of astrocytes, which can deliver nutrients and active substances to the brain …

The glymphatic system is a fluid transport network of cerebrospinal fluid (CSF) entering the
brain along arterial perivascular spaces, exchanging with interstitial fluid (ISF), ultimately …

The glymphatic system transports cerebrospinal fluid (CSF) into the brain via arterial
perivascular spaces and removes interstitial fluid from the brain along perivenous spaces …

Objective In the brain, protein waste removal is partly performed by paravascular pathways
that facilitate convective exchange of water and soluble contents between cerebrospinal …

Brain fluids are rigidly regulated to provide stable environments for neuronal function, eg,
low K+, Ca 2+, and protein to optimise signalling and minimise neurotoxicity. At the same …

The glymphatic system is responsible for the clearance of the potentially harmful metabolic
waste of the central nervous system. The prevalent theory is that the cerebrospinal fluid …