Lymph nodes (LNs) are important hubs for metastatic cell arrest and growth, immune
modulation, and secondary dissemination to distant sites through a series of mechanisms …

Lymph nodes are the most common sites of metastasis in cancer patients. Nodal disease
status provides great prognostic power, but how lymph node metastases should be treated …

Cancer patients with lymph node (LN) metastases have a worse prognosis than those
without nodal disease. However, why LN metastases correlate with reduced patient survival …

Lymph nodes are initial sites for cancer metastasis in many solid tumors. However, their role
in cancer progression is still not completely understood. Emerging evidence suggests that …

The mechanisms by which malignant tumors leave the primary tumor site, invade
lymphatics, and metastasize to regional lymph nodes (RLNs) are complex and interrelated …

Metastasis is a major cause of death in patients with cancer. The two main routes for cancer
cell dissemination are the blood and lymphatic systems. The underlying mechanism of …

Cancer metastasis is the process by which primary cancer cells invade through the
lymphatic or blood vessels to distant sites. The molecular mechanisms by which cancer cells …

Tumor-associated lymphatic vessels play an important role in tumor progression, mediating
lymphatic dissemination of malignant cells to tumor-draining lymph nodes and regulating …

Metastasis to the regional lymph node is the most important prognostic indicator for the
outcomes of patients with sold cancer. In general, it is well recognized that cancer …

Highlights•Tumours induce growth and remodelling of lymphatics which is linked with
metastasis.•Lymphatic vessels modulate antitumour immunity in tumours and draining lymph …