Background: Nod-like receptor family, pyrin domain containing 3 (NLRP3) is an important
cytosolic sensor of cellular stress and infection. Once activated, NLRP3 forms a multiprotein …

Background The NOD-like receptor (NLR) family pyrin domain-containing 3 (NLRP3)
inflammasomes are intracellular protein complexes that orchestrate immune responses …

Microbial sensing plays essential roles in the innate immune response to pathogens. In
particular, NLRP3 forms a multiprotein inflammasome complex responsible for the …

Citrobacter rodentium is an enteric bacterial pathogen of the mouse intestinal tract that
triggers inflammatory responses resembling those of humans infected with …

Activation of the nod-like receptor protein 3 (NLRP3) leads to the release of the
proinflammatory cytokine IL-1β, which then facilitates pathogen control by macrophages …

Members of the nucleotide‐binding, oligomerization domain (NOD)‐like receptor (NLR)
proteins assemble into a multiprotein platform, known as the inflammasome, to induce …

The nucleotide-binding domain, leucine-rich-repeat-containing family, pyrin domain-
containing 3 (NLRP3) inflammasome is responsible for sensing and regulating the …

The inflammasome is composed of nucleotide-binding, oligomerization domain (NOD)-like
receptor (NLR) proteins, and leads to caspase-1 activation and subsequent secretion of the …

Background The inflammasome is an intracellular protein complex triggered by exposure to
intracellular pathogens, its components or other endogenous proteins. It leads to the …

The inflammasome is an emerging new pathway in innate immune defense against
microbial infection or endogenous danger signals. The inflammasome stimulates activation …