Gene expression profiling in multiple sclerosis brain

R Dutta, BD Trapp - Neurobiology of disease, 2012 - Elsevier
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system and the leading cause of non-traumatic neurological disability in young …

Gene expression changes underlying cortical pathology: clues to understanding neurological disability in multiple sclerosis

R Dutta - Multiple Sclerosis Journal, 2013 - journals.sagepub.com
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system with an unknown etiology. The clinical disease course is variable, with the …

Genomics in multiple sclerosis—current state and future directions

M Comabella, R Martin - Journal of neuroimmunology, 2007 - Elsevier
Microarray-based gene expression profiling of large numbers of genes or even the whole
genome has only recently become possible. Several studies have employed this technology …

Peripheral blood gene expression signature mirrors central nervous system disease: the model of multiple sclerosis

A Achiron, M Gurevich - Autoimmunity reviews, 2006 - Elsevier
Global gene expression analysis using cDNA microarrays has proven to be a sensitive
method to gain insight into molecular pathways mediating multiple sclerosis (MS) activity …

Identification of Key Genes and Regulatory Pathways in Multiple Sclerosis Brain Samples: A Meta-Analysis of Micro-Array Datasets

MI Jansen, A Castorina - International Journal of Molecular Sciences, 2023 - mdpi.com
Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system (CNS)
whose aetiology is only partly understood. Investigating the intricate transcriptional changes …

Genomics and proteomics: role in the management of multiple sclerosis

L Kappos, L Achtnichts, F Dahlke, J Kuhle… - Journal of …, 2005 - Springer
Epidemiological studies and neuro-imaging have provided important insights into the
natural course and prognostic factors of multiple sclerosis (MS), but our ability to predict …

Genomics in multiple sclerosis

M Habek, F Borovečki, VV Brinar - Clinical neurology and neurosurgery, 2010 - Elsevier
Multiple sclerosis (MS) is chronic, inflammatory disease of the central nervous system that
mainly affects young adults and is characterized with dissemination of demyelinating lesions …

cDNA microarray analysis in multiple sclerosis lesions: detection of genes associated with disease activity

MP Mycko, R Papoian, U Boschert, CS Raine… - Brain, 2003 - academic.oup.com
Abstract cDNA microarray analysis of the regions of pathologically proven different activity of
multiple sclerosis lesions was performed. Major differences in gene expression (DGE) …

Identification of molecular biomarkers for multiple sclerosis

SC Fossey, CL Vnencak-Jones, NJ Olsen… - The Journal of Molecular …, 2007 - Elsevier
Multiple sclerosis is a demyelinating disease of the central nervous system with a presumed
autoimmune etiology. Previous microarray analyses identified conserved gene expression …

Blood transcriptional signatures of multiple sclerosis: unique gene expression of disease activity

A Achiron, M Gurevich, N Friedman… - Annals of Neurology …, 2004 - Wiley Online Library
Multiple sclerosis (MS) is a central nervous system disease with an unpredictable course
and outcome. Peripheral blood mononuclear cells (PBMCs) are involved in the disease …