Psoriasis is a chronic inflammatory skin disease of unknown etiology. Previous studies
showed that short-term, 5–7 d-long application of imiquimod (IMQ), a TLR7 agonist, to the …

Psoriasis is a chronic skin disease associated with deregulated activation of immune cells
and keratinocytes. In this study, we used the imiquimod (IMQ)-induced mouse model of …

Many autoimmune disorders such as psoriasis lead to the alteration of skin components
which generally manifests as unwanted topical symptoms. One of the most widely approved …

Psoriasis is an autoinflammatory skin disease of unknown etiology. Topical application of
Aldara cream containing the Toll-like receptor (TLR) 7 agonist Imiquimod (IMQ) onto patients …

Background Imiquimod (IMQ) produces a cutaneous phenotype in mice frequently studied
as an acute model of human psoriasis. Whether this phenotype depends on strain or sex …

Psoriasis is a common chronic inflammatory skin disease. The diversity and heterogeneity of
immune cells in human skin have been studied in recent years, but the spatial distribution of …

Psoriasis is an inflammatory disease of the skin affecting 2–3% of the population,
characterized by a thickening of the epidermis and immune infiltrates throughout the dermis …

Epidermal Langerhans cells (LCs) are spatially separated from dermal dendritic cells (DCs)
in healthy human skin. In active psoriasis, maintained by local production of IL-23 and IL-17 …

Several subtypes of APC s are found in psoriasis patients, but their involvement in disease
pathogenesis is poorly understood. Here, we investigated the contribution of Langerhans …

Abstract Background Langerhans cells (LCs) are epidermis-resident dendritic cells that
sense and mediate stimuli from skin and outside world, and participate in various skin …