Thyroid hormone replacement therapy (THRT, generally using oral levothyroxine (LT4)) is a
safe, effective means of treating hypothyroidism. However, a proportion of LT4-treated …

Background. Primary hypothyroidism is characterized by reduced quality of life (QoL).
Although thyrotropin (TSH) is utilized as the primary indicator of thyroid disease and …

Objectives: According to one hypothesis, the popularity of levothyroxine (LT< sub>
4</sub>)/liothyronine (LT< sub> 3</sub>) combination therapy relates to weight loss. The …

Objective The effects of levothyroxine (LT4)/liothyronine (LT3) combination therapy on
quality of life (QoL) in hypothyroid patients former on LT4 monotherapy have been …

Objectives: Hypothyroidism results in decreased mood and neurocognition, weight gain,
fatigue, and many other undesirable symptoms. The American Association of Clinical …

ContextStandard therapy for patients with primary hypothyroidism is replacement with
synthetic thyroxine, which undergoes peripheral conversion to triiodothyronine, the active …

Objective Dissatisfaction with treatment and impaired quality of life (QOL) are reported
among people with treated hypothyroidism. We aimed to gain insight into this. Design and …

The aim of this study was to investigate in a longitudinal approach whether levothyroxine
(LT4) substitution has a different impact on quality of life (QoL) and thyroid related QoL in …

Background: Approximately 15% more patients taking levothyroxine (LT4) report impaired
quality of life compared to controls. This could be explained by additional diagnoses …

In the 1970s, treatment with thyroid extract was superseded by levothyroxine, a synthetic l
form of tetraiodothyronine. Since then, no major innovation has emerged for the treatment of …