Objectives To explore whether a strategy of more intensive antibiotic therapy leads to
emergence or prolongation of renal failure in intensive care patients. Design Secondary …

Background Reduced duration of antibiotic treatment might contain the emergence of
multidrug-resistant bacteria in intensive care units. We aimed to establish the effectiveness …

Objectives: In critically ill patients receiving continuous renal replacement therapy, we aimed
to assess the variability of antibiotic trough concentrations, the influence of effluent flow rates …

Background Intensive care units (ICUs) are specialized units where patients with critical
conditions are admitted for getting specialized and individualized medical treatment. High …

A common cause of acute kidney injury (AKI) is sepsis, which makes appropriate dosing of
antibiotics in these patients essential. Drug dosing in critically ill patients with AKI, however …

Abstract Background and Objectives Although dose optimization studies have been
performed for piperacillin and tazobactam separately, a combined integral analysis is not yet …

Although early and appropriate antibiotic therapy remains the most important intervention for
successful treatment of septic shock, data guiding optimization of beta-lactam prescription in …

Objectives: To determine whether the probability of target attainment over 72 hours of initial
therapy with beta-lactam (cefepime, ceftazidime, piperacillin/tazobactam) and carbapenem …

There is currently an increase in the emergence of multidrug-resistant bacteria (MDR)
worldwide, requiring the development of novel antibiotics. However, it is not only the choice …

Optimal dosing of antimicrobial therapy is pivotal to increase the likelihood of survival in
critically ill patients with sepsis. Drug exposure that maximizes bacterial killing, minimizes …