Shattering barriers toward clinically meaningful MSC therapies

O Levy, R Kuai, EMJ Siren, D Bhere, Y Milton… - Science …, 2020 - science.org
More than 1050 clinical trials are registered at FDA. gov that explore multipotent
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …

Challenges and advances in clinical applications of mesenchymal stromal cells

T Zhou, Z Yuan, J Weng, D Pei, X Du, C He… - Journal of hematology & …, 2021 - Springer
Mesenchymal stromal cells (MSCs), also known as mesenchymal stem cells, have been
intensely investigated for clinical applications within the last decades. However, the majority …

A brief overview of global trends in MSC-based cell therapy

D Jovic, Y Yu, D Wang, K Wang, H Li, F Xu… - Stem cell reviews and …, 2022 - Springer
Human mesenchymal stem cells (MSCs), also known as mesenchymal stromal cells or
medicinal signaling cells, are important adult stem cells for regenerative medicine, largely …

Challenges for mesenchymal stromal cell therapies

I Martin, J Galipeau, C Kessler, K Le Blanc… - Science translational …, 2019 - science.org
Challenges for mesenchymal stromal cell therapies | Science Translational Medicine news
careers commentary Journals Science Science brought to you byGoogle Indexer Log in science …

Mesenchymal stromal cells: clinical challenges and therapeutic opportunities

J Galipeau, L Sensébé - Cell stem cell, 2018 - cell.com
Mesenchymal stromal cells (MSCs) have been the subject of clinical trials for more than a
generation, and the outcomes of advanced clinical trials have fallen short of expectations …

Mesenchymal stromal cell therapeutic delivery: translational challenges to clinical application

H Caplan, SD Olson, A Kumar, M George… - Frontiers in …, 2019 - frontiersin.org
For several decades, multipotent mesenchymal stromal cells (MSCs) have been extensively
studied for their therapeutic potential across a wide range of diseases. In the preclinical …

Mesenchymal stromal cell therapies: immunomodulatory properties and clinical progress

X Wu, J Jiang, Z Gu, J Zhang, Y Chen, X Liu - Stem cell research & …, 2020 - Springer
Mesenchymal stromal cells (MSCs) are a subset of heterogeneous non-hematopoietic
fibroblast-like cells that can differentiate into cells of multiple lineages, such as …

Concise review: adult mesenchymal stromal cell therapy for inflammatory diseases: how well are we joining the dots?

MD Griffin, SJ Elliman, E Cahill, K English… - Stem …, 2013 - academic.oup.com
Mesenchymal stromal (stem) cells (MSCs) continue to be a strong area of focus for
academic-and industry-based researchers who share the goal of expanding their …

Engineering mesenchymal stem cells for regenerative medicine and drug delivery

JS Park, S Suryaprakash, YH Lao, KW Leong - Methods, 2015 - Elsevier
Researchers have applied mesenchymal stem cells (MSC) to a variety of therapeutic
scenarios by harnessing their multipotent, regenerative, and immunosuppressive properties …

Mesenchymal stem cell therapy: Two steps forward, one step back

J Ankrum, JM Karp - Trends in molecular medicine, 2010 - cell.com
Mesenchymal stem cell (MSC) therapy is poised to establish a new clinical paradigm;
however, recent trials have produced mixed results. Although MSC were originally …