Sickle cell disease (SCD) is the name for a group of genetic blood disorders caused by
sickle hemoglobin (Hb S). The 2 key features of SCD are chronic hemolytic anemia and …

Sickle cell disease (SCD) is a complex, clinically heterogeneous disorder affecting
approximately 100,000 individuals in the United States and millions worldwide. The disease …

Sickle cell disease (SCD) is a monogenetic disorder due to a single base-pair point mutation
in the β-globin gene resulting in the substitution of the amino acid valine for glutamic acid in …

As more children are appropriately being diagnosed, the burden of sickle cell disease is
increasing greatly in Africa and in high-resource countries such as the United States and …

Sickle cell disease (SCD) is a serious and life-threatening disease that affects approximately
1 in 600 African Americans [1, 2]. In 1910, Herrick described the first patient with SCD, and …

Since the description of the first case of sickle cell disease (SCD) in 1910 by James Herrick
and Ernest Irons, much has been learned about the disorder and improvements in care have …

Importance Sickle cell disease (SCD) is an inherited disorder of hemoglobin, characterized
by formation of long chains of hemoglobin when deoxygenated within capillary beds …

Once a fatal disease of childhood, more than 95% of patients born today with sickle cell
disease (SCD) in developed countries are expected to survive into adulthood, largely …

Sickle cell disease (SCD) is a group of complex genetic disorders with multisystem
manifestations. This statement provides pediatricians in primary care and subspecialty …

Early identification of infants with sickle cell disease (SCD) by newborn screening, now
universal in all 50 states in the US, has improved survival, mainly by preventing …