Left ventricular remodeling after myocardial infarction: from physiopathology to treatment

SA Leancă, D Crișu, AO Petriș, I Afrăsânie, A Genes… - Life, 2022 - mdpi.com
Myocardial infarction (MI) is the leading cause of death and morbidity worldwide, with an
incidence relatively high in developed countries and rapidly growing in developing …

Left ventricular remodelling post-myocardial infarction: pathophysiology, imaging, and novel therapies

S Frantz, MJ Hundertmark… - European heart …, 2022 - academic.oup.com
Most patients survive acute myocardial infarction (MI). Yet this encouraging development
has certain drawbacks: heart failure (HF) prevalence is increasing and patients affected tend …

Mechanisms of postinfarct left ventricular remodeling

BA French, CM Kramer - Drug Discovery Today: Disease Mechanisms, 2007 - Elsevier
Heart failure secondary to myocardial infarction (MI) remains a major source of morbidity
and mortality. Long-term outcome after MI can be largely be defined in terms of its impact on …

Postinfarct left ventricular remodelling: a prevailing cause of heart failure

A Galli, F Lombardi - Cardiology research and practice, 2016 - Wiley Online Library
Heart failure is a chronic disease with high morbidity and mortality, which represents a
growing challenge in medicine. A major risk factor for heart failure with reduced ejection …

Postinfarction left ventricular remodeling: a pathophysiological and therapeutic review

Z Yousef, SR Redwood, MS Marber - Cardiovascular drugs and therapy, 2000 - Springer
Over the last 50 years, studies investigating the pathogenesis of left ventricular dysfunction
have resulted in many potential therapeutic targets being identified and novel classes of …

Unresolved issues in left ventricular postischemic remodeling and progression to heart failure

E Gronda, S Sacchi, G Benincasa… - Journal of …, 2019 - journals.lww.com
In the past decades, myocardial infarction periacute mortality markedly declined since
coronary reperfusion therapy has been adopted. Despite immediate benefits of coronary …

Pharmacological modulation of cardiac remodeling after myocardial infarction

W Zhao, J Zhao, J Rong - Oxidative Medicine and Cellular …, 2020 - Wiley Online Library
Cardiac remodeling describes a series of structural and functional changes in the heart after
myocardial infarction (MI). Adverse post‐MI cardiac remodeling directly jeopardizes the …

Left ventricular remodeling in the post-infarction heart: a review of cellular, molecular mechanisms, and therapeutic modalities

JJ Gajarsa, RA Kloner - Heart failure reviews, 2011 - Springer
As more patients survive myocardial infarctions, the incidence of heart failure increases.
After an infarction, the human heart undergoes a series of structural changes, which are …

Postinfarction left ventricular remodelling: where are the theories and trials leading us?

ZR Yousef, SR Redwood, MS Marber - Heart, 2000 - heart.bmj.com
While mortality from overt ischaemic heart disease is falling, that from heart failure is
increasing and reaching epidemic proportions. 1 Although an aging population is partly …

Remodeling in the ischemic heart: the stepwise progression for heart

JG Mill, I Stefanon, L Dos Santos… - Brazilian Journal of …, 2011 - SciELO Brasil
Coronary artery disease is the leading cause of death in the developed world and in
developing countries. Acute mortality from acute myocardial infarction (MI) has decreased in …