Overproduction of neuronal nitric oxide synthase (nNOS)-derived NO is detrimental during
cerebral ischemia. Normobaric hyperoxia (NBO) has been shown to be neuroprotective …

Objectives: Oxygen therapy has been long considered a logical therapy for ischemic stroke.
Our previous studies showed that normobaric hyperoxia (normobaric hyperoxia (NBO), 95 …

Hyperoxia causes a transient decrease in CBF, followed by a later rise. The mediators of
these effects are not known. We used mice lacking endothelial or neuronal nitric oxide …

Normobaric hyperoxia (NBO) has been shown to be neuro-and vaso-protective during
ischemic stroke. However, the underlying mechanisms remain to be fully elucidated …

Background and Purpose—The efficacy of neuroprotective approaches in stroke may be
influenced by existing comorbidities. Here, we compared the effects of normobaric hyperoxia …

OBJECTIVE: The collateral circulation development is considered as a compensatory
inherent mechanism to restore damaged blood perfusion after ischemia. We aimed to detect …

In a thromboembolic stroke model after reperfusion by recombinant tissue plasminogen
activator (rt-PA), we aimed to determine whether therapeutic hypothermia (TH) and ethanol …

Angiotensin II (Ang II) receptor blockade is beneficial in stroke, possibly due to attenuation of
vascular oxidative stress. Mice genetically targeted for the superoxide-forming vascular …

Background and Purpose Cessation of blood flow to the brain, for even a few minutes, sets
in motion a potential reversible cascade of events resulting in neuronal cell death. Oxygen …

Excess production of reactive oxygen species (ROS) critically contributes to occurrence of
reperfusion injury, the paradoxical response of ischemic brain tissue to restoration of …