Timolol is a beta adrenergic antagonist in 0.25% or 0.5% eyedrop solution for glaucoma. In
a double‐blind crossover study in healthy males we measured systemic beta blockade …

Background. To investigate the pharmacological basis of systemic side effects of ophthalmic
timolol, we estimated the systemic bioavailability of 0.5% timolol eyedrops and compared …

Synopsis: Timolol maleate 1 is a nonselective β-blocking drug used for the topical treatment
of increased intraocular pressure in patients with chronic open angle glaucoma. In …

Timolol eyedrops may cause systemic side-effects in glaucoma patients due to absorption of
the drug into systemic circulation. In a previous study, timolol concentrations in plasma were …

Timolol maleate is a non‐selective β‐adrenoceptor antagonist currently used mainly as an
ocular preparation for the treatment of glaucoma and ocular hypertension. Despite the …

Timolol was used by 37 glaucoma patients from 1 to 18 months. Of those 37 patients, 31
used timolol for three months or longer and 7 used timolol for over one year. Timolol …

Symptoms and findings arising from the systemic beta blockade caused by topical ocularly
applied timolol appear shortly after drug application. We studied the systemic absorption of …

Plasma timolol levels were measured in our timolol-treated glaucoma patients employing
three protocols:(1) measurements in ten patients over age 60 on chronic timolol therapy …

Timolol is now widely used in the treatment of glaucoma but its mechanism of action is
unclear. The drug decreases aqueous humor formation by the ciliary processes and is a …

The absorption of timolol after topical administration to the eye was studied in 11 healthy
volunteers and in 5 patients with bilateral open angle glaucoma. The volunteers received 2 …