Background & Aims: Gain-of-function trypsin mutations cause acute pancreatitis and chronic
pancreatitis. Loss of trypsin inhibitor function may have similar effects. We investigated the …

Background: Mutations in the PRSS1 gene explain most occurrences of hereditary
pancreatitis (HP) but many HP families have no PRSS1 mutation. Recently, an association …

Abstract Background/Aims: Tropical pancreatitis (TP) refers to a severe type of idiopathic
chronic pancreatitis that develops in children in tropical regions of Africa and southern Asia …

Background The aim was to describe genetic, clinical and morphological features in a large,
multicentre European cohort of patients with SPINK1 related pancreatitis, in comparison with …

Background and aims: Two common haplotypes of the serine protease inhibitor Kazal type 1
(SPINK1) gene have been shown to increase the risk for chronic pancreatitis. A haplotype …

Variations in the SPINK1 gene (encoding pancreatic secretory trypsin inhibitor (PSTI)) are
associated with chronic pancreatitis. We have recently determined the functional …

Objectives: Rare pathogenic variants in the SPINK1, PRSS1, CTRC, and CFTR genes have
been strongly associated with a risk of developing chronic pancreatitis (CP). However, their …

Background & Aims: Tropical pancreatitis, including tropical calcific pancreatitis and
fibrocalculous pancreatic diabetes, is endemic in parts of Asia and Africa. In a preliminary …

Variants of the SPINK1 gene encoding pancreatic secretory trypsin inhibitor have been
described in association with chronic pancreatitis (CP). These alterations are believed to …

Background and aims: Mutations in the cationic trypsinogen (protease, serine, 1 (trypsin 1);
PRSS1) gene are causally associated with recurrent acute and chronic pancreatitis. We …