Retinoblastoma is a rare childhood cancer of the developing retina, and studies on this
orphan disease have led to fundamental discoveries in cancer biology. Retinoblastoma has …

Retinoblastoma is a retinal cancer that affects children and is the most prevalent intraocular
tumor worldwide. Despite tremendous breakthroughs in our understanding of the …

Retinoblastoma is a retinal cancer that is initiated in response to biallelic loss of RB1 in
almost all cases, together with other genetic/epigenetic changes culminating in the …

With an average incidence of 1 in every 18,000 live births, retinoblastoma is a rare type of
intraocular tumour found to affect patients during their early childhood. It is curable if …

Introduction: Retinoblastoma is the most common primary intraocular malignancy in
children. Treatment success approaches 100% at specialized centers with globe-salvaging …

Retinoblastoma, an intraocular pediatric cancer, develops in the embryonic retina following
biallelic loss of RB1. However, there is a wide range of genetic and epigenetic changes that …

Retinoblastoma has contributed much to the understanding of cancer. It provided the classic
'two-hit model'for oncogenesis and helped to identify the first tumor suppressor gene RB1 …

Studies on retinoblastoma have been at the heart of many of the landmark discoveries in
cancer genetics over the past 35 years. However, these advances in the laboratory have …

PURPOSE: To provide an overview of the current clinical management of retinoblastoma by
discussing the trends in the categorization, treatment, and recent advances in molecular …

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