Immunotherapy for the first-line treatment of patients with metastatic non–small cell lung cancer

P Martinez, S Peters, T Stammers, JC Soria - Clinical Cancer Research, 2019 - AACR
Immunotherapy has fundamentally changed the treatment landscape for many patients with
cancer. mAbs targeting programmed cell death-1 (PD-1), programmed cell death ligand-1 …

At the crossroads of immunotherapy for oncogene-addicted subsets of NSCLC

I Otano, AC Ucero, J Zugazagoitia… - Nature reviews Clinical …, 2023 - nature.com
Non-small-cell lung cancer (NSCLC) has become a paradigm of precision medicine, with
the discovery of numerous disease subtypes defined by specific oncogenic driver mutations …

Molecular mechanisms and targeted therapies including immunotherapy for non-small cell lung cancer

T Nagano, M Tachihara… - Current cancer drug …, 2019 - ingentaconnect.com
Lung cancer is the leading cause of cancer death worldwide. Molecular targeted therapy
has greatly advanced the field of treatment for non-small cell lung cancer (NSCLC), which …

[HTML][HTML] New advances in immunotherapy for non-small cell lung cancer

H Qin, F Wang, H Liu, Z Zeng, S Wang… - American journal of …, 2018 - ncbi.nlm.nih.gov
Immunotherapy is one of the methods that can change the survival rate of patients with
malignant tumors, in addition to surgery therapy, radiotherapy, chemotherapy and targeted …

[HTML][HTML] Conquering lung cancer: current status and prospects for the future

R Pirker - Pulmonology, 2020 - Elsevier
Lung cancer is a major global health problem. Several strategies are required to conquer
this cancer. Stricter implementations of tobacco control measures are necessary. Early …

[HTML][HTML] Primary and acquired resistance to immunotherapy in lung cancer: unveiling the mechanisms underlying of immune checkpoint blockade therapy

L Boyero, A Sánchez-Gastaldo, M Alonso… - Cancers, 2020 - mdpi.com
Simple Summary Immuno-oncology has redefined the treatment of lung cancer, with the
ultimate goal being the reactivation of the anti-tumor immune response. This has led to the …

[HTML][HTML] Programmed cell death protein-1/programmed cell death ligand-1 pathway inhibition and predictive biomarkers: understanding transforming growth factor …

M Santarpia, M González-Cao, S Viteri… - … lung cancer research, 2015 - ncbi.nlm.nih.gov
A deeper understanding of the key role of the immune system in regulating tumor growth
and progression has led to the development of a number of immunotherapies, including …

Immune checkpoint modulation for non–small cell lung cancer

JC Soria, A Marabelle, JR Brahmer, S Gettinger - Clinical cancer research, 2015 - AACR
Therapies targeting immune checkpoints have recently shown encouraging activity in
patients with heavily pretreated advanced non–small cell lung cancer (NSCLC) …

Response rates to single-agent chemotherapy after exposure to immune checkpoint inhibitors in advanced non-small cell lung cancer

G Schvartsman, SA Peng, G Bis, JJ Lee… - Lung cancer, 2017 - Elsevier
Introduction Exploratory analysis of clinical trials in various tumor types have demonstrated
potential improvements in overall response rate (ORR) to chemotherapy after exposure to …

New modalities of cancer treatment for NSCLC: focus on immunotherapy

M Davies - Cancer management and research, 2014 - Taylor & Francis
Recent advances in the understanding of immunology and antitumor immune responses
have led to the development of new immunotherapies, including vaccination approaches …