Abstract BH3 (Bcl-2 homology 3)-only proteins of the Bcl-2 family play an essentialrole in
apoptosis. In this study, a novel human BH3-only protein, Bcl-2-interacting mediator (Bim) γ …

Bim protein is one of the BH3-only proteins, members of the Bcl-2 family that have only one
of the Bcl-2 homology regions, BH3. BH3-only proteins are essential initiators of apoptotic …

Doxorubicin and other anthracycline compounds exert their anti-cancer effects by causing
DNA damage and initiating cell cycle arrest in cancer cells, followed by apoptosis. DNA …

Bim (Bcl-2-interacting mediator of cell death) is a member of the BH3 domain-only subgroup
of Bcl-2 family members, for which three splice variants have been described. Bim is …

BH3-only protein Bim is a critical regulator of apoptosis and plays an essential role in
mammalian development, but the characterization of Bim and its isoforms in hepatocellular …

Proapoptotic Bcl-2 homology 3-only protein Bim plays an important role in Bax/Bak-
mediated cytochrome c release and apoptosis. Here, we provide evidence for a novel …

Proteins of the Bcl-2 family are critical regulators of apoptosis, but how its BH3-only
members activate the essential effectors Bax and Bak remains controversial. The indirect …

Certain members of the Bcl‐2 family inhibit apoptosis while others facilitate this
physiological process of cell death. An expression screen for proteins that bind to Bcl‐2 …

Bim is a proapoptotic BH3‐domain‐only member of the Bcl‐2 family, and its expression is
regulated both transcriptionally and posttranslationally. We developed an in vitro system …

BH3-only proteins constitute major proportion of pro-apoptotic members of B-cell lymphoma
2 (Bcl-2) family of apoptotic regulatory proteins and participate in embryonic development …