Blockade of phospholipid scramblase 1 with its N-terminal domain antibody reduces tumorigenesis of colorectal carcinomas in vitro and in vivo
CW Fan, CY Chen, KT Chen, CR Shen, YB Kuo… - Journal of translational …, 2012 - Springer
Background Membrane-bound phospholipid scramblase 1 (PLSCR1) is involved in both
lipid trafficking and cell signaling. Previously, we showed that PLSCR1 is overexpressed in …
lipid trafficking and cell signaling. Previously, we showed that PLSCR1 is overexpressed in …
RNA interference‑mediated downregulation of phospholipid scramblase 1 expression in primary liver cancer in vitro
L Gui, YW Zhu, Q Xu, JJ Huang, P Hua… - Oncology …, 2020 - spandidos-publications.com
Abstract Phospholipid scramblase 1 (PLSCR1) serves a function in the pathogenesis and
progression of various types of cancer. However, the role of PLSCR1 in human primary liver …
progression of various types of cancer. However, the role of PLSCR1 in human primary liver …
Identification of phospholipid scramblase 1 as a biomarker and determination of its prognostic value for colorectal cancer
YB Kuo, CC Chan, CA Chang, CW Fan, RP Hung… - Molecular …, 2011 - Springer
The purpose of this study was to examine the expression of phospholipid scramblase 1
(PLSCR1) in tumor tissues and plasma specimens of patients with colorectal cancer (CRC) …
(PLSCR1) in tumor tissues and plasma specimens of patients with colorectal cancer (CRC) …
Silencing phospholipid scramblase 1 expression by RNA interference in colorectal cancer and metastatic liver cancer
W Cui, SY Li, JF Du, ZM Zhu, P An - Hepatobiliary & pancreatic diseases …, 2012 - Elsevier
Background Phospholipid scramblase 1 (PLSCR1) not only participates in the transbilayer
movement of phospholipids, but also plays a role in the pathogenesis and progression of …
movement of phospholipids, but also plays a role in the pathogenesis and progression of …
Phospholipid scramblase 1.
Y Huang, Q Zhao, GQ Chen - Sheng li xue bao:[Acta Physiologica …, 2006 - europepmc.org
Phospholipid scramblase 1 (PLSCR1) is a calcium-binding, multiply palmitoylated type II
endofacial plasma membrane protein, while unpalmitoylated PLSCR1 protein can import …
endofacial plasma membrane protein, while unpalmitoylated PLSCR1 protein can import …
Antileukemic roles of human phospholipid scramblase 1 gene, evidence from inducible PLSCR1-expressing leukemic cells
Y Huang, Q Zhao, CX Zhou, ZM Gu, D Li, HZ Xu… - Oncogene, 2006 - nature.com
Abstract Phospholipid scramblase 1 (PLSCR1) is a multiply palmitoylated protein which is
localized in either the cell membrane or nucleus depending on its palmitoylated state. The …
localized in either the cell membrane or nucleus depending on its palmitoylated state. The …
Two c-Myc binding sites are crucial in upregulating the expression of human phospholipid scramblase 1 gene
JM Vinnakota, SN Gummadi - Biochemical and biophysical research …, 2016 - Elsevier
Abstract Human phospholipid scramblase 1 (hPLSCR1) is a type II endofacial membrane
protein which mediates bi-directional transport of phospholipids across the plasma …
protein which mediates bi-directional transport of phospholipids across the plasma …
Identification and characterization of the novel nuclease activity of human phospholipid scramblase 1
Background Human phospholipid scramblase 1 (hPLSCR1) was initially identified as a Ca
2+ dependent phospholipid translocator involved in disrupting membrane asymmetry …
2+ dependent phospholipid translocator involved in disrupting membrane asymmetry …
Antibody Against N‐terminal Domain of Phospholipid Scramblase 1 Induces Apoptosis in Colorectal Cancer Cells Through the Intrinsic Apoptotic Pathway
CY Chen, JS Chen, YP Chou, YB Kuo… - Chemical biology & …, 2014 - Wiley Online Library
Phospholipid scramblase 1 involve in biological processes including phospholipid
movement, proliferation, and apoptosis. Treatment with an antiphospholipid scramblase 1 …
movement, proliferation, and apoptosis. Treatment with an antiphospholipid scramblase 1 …
Phospholipid scramblases: Role in cancer progression and anticancer therapeutics
HG Behuria, S Dash, SK Sahu - Frontiers in Genetics, 2022 - frontiersin.org
Phospholipid scramblases (PLSCRs) that catalyze rapid mixing of plasma membrane lipids
result in surface exposure of phosphatidyl serine (PS), a lipid normally residing to the inner …
result in surface exposure of phosphatidyl serine (PS), a lipid normally residing to the inner …