Pathogenesis of Cerebral Cryptococcus neoformans Infection after Fungemia

F Chrétien, O Lortholary, I Kansau… - The Journal of …, 2002 - academic.oup.com
The pathogenesis of cerebral infection after Cryptococcus neoformans fungemia in outbred
mice was investigated. Confocal microscopy and cultures on ficoll-hypaque gradient …

Cryptococcus neoformans Gene Expression during Murine Macrophage Infection

W Fan, PR Kraus, MJ Boily, J Heitman - Eukaryotic cell, 2005 - Am Soc Microbiol
The fungal pathogen Cryptococcus neoformans survives phagocytosis by macrophages and
proliferates within, ultimately establishing latent infection as a facultative intracellular …

Galleria mellonella as a Model System To Study Cryptococcus neoformans Pathogenesis

E Mylonakis, R Moreno, JB El Khoury… - Infection and …, 2005 - Am Soc Microbiol
Evaluation of Cryptococcus neoformans virulence in a number of nonmammalian hosts
suggests that C. neoformans is a nonspecific pathogen. We used the killing of Galleria …

[PDF][PDF] Dismantling the Cryptococcus coat

CA D'Souza, J Heitman - Trends in microbiology, 2001 - Citeseer
Cryptococcus neoformans is an encapsulated yeast and an opportunistic fungal pathogen
responsible for lifethreatening infections of the central nervous system (CNS) in HIV-1 …

[HTML][HTML] A major role for capsule-independent phagocytosis-inhibitory mechanisms in mammalian infection by Cryptococcus neoformans

CD Chun, JCS Brown, HD Madhani - Cell host & microbe, 2011 - cell.com
The antiphagocytic polysaccharide capsule of the human fungal pathogen Cryptococcus
neoformans is a major virulence attribute. However, previous studies of the pleiotropic …

The primary target organ of Cryptococcus gattii is different from that of Cryptococcus neoformans in a murine model

P Ngamskulrungroj, Y Chang, E Sionov… - MBio, 2012 - Am Soc Microbiol
Cryptococcosis is caused by the opportunistic pathogen Cryptococcus neoformans or by the
primary pathogen Cryptococcus gattii. Epidemiological studies suggest that patients infected …

[HTML][HTML] Calcineurin is required for hyphal elongation during mating and haploid fruiting in Cryptococcus neoformans

MC Cruz, DS Fox, J Heitman - The EMBO journal, 2001 - embopress.org
Cryptococcus neoformans is a fungal pathogen that causes meningitis in
immunocompromised patients. Its growth is sensitive to the immunosuppressants FK506 …

Cryptococcus neoformans induces alterations in the cytoskeleton of human brain microvascular endothelial cells

SHM Chen, MF Stins, SH Huang… - Journal of medical …, 2003 - microbiologyresearch.org
The fungal pathogen Cryptococcus neoformans has a predilection for the central nervous
system (CNS), resulting in devastating meningoencephalitis. At present, it is unclear how C …

[HTML][HTML] Pulmonary infection with an interferon-γ-producing Cryptococcus neoformans strain results in classical macrophage activation and protection

SE Hardison, S Ravi, KL Wozniak, ML Young… - The American journal of …, 2010 - Elsevier
Alternative macrophage activation is associated with exacerbated disease in murine models
of pulmonary cryptococcosis. The present study evaluated the efficacy of interferon-γ …

Adherence to and damage of endothelial cells by Cryptococcus neoformans in vitro: role of the capsule

AS Ibrahim, SG Filler, MS Alcouloumre… - Infection and …, 1995 - Am Soc Microbiol
Escape from the intravascular compartment is likely a critical step in the development of
hematogenously disseminated cryptococcal infections, such as meningitis. The capsule of …