The structure‐specific FEN‐1 endonuclease has been implicated in various cellular
processes, including DNA replication, repair and recombination. In vertebrate cells …

Human Fen1 can be acetylated in vivo and in vitro resulting in reduced endonuclease and
exonuclease activities in vitro. Acetylation occurs at four lysines located at the C terminus of …

Flap endonuclease 1 (FEN-1) is a 5′–3′ flap exo-/endonuclease that plays an important
role in Okazaki fragment maturation, nonhomologous end joining of double-stranded DNA …

Abstract Flap endonuclease 1 (FEN1), a structure-specific endo-and exonuclease, has
multiple functions that determine essential biological processes, such as cell proliferation …

Abstract Flap endonuclease-1 (FEN1) is a multifunctional, structure-specific nuclease that
has a critical role in maintaining human genome stability. FEN1 mutations have been …

Abstract Flap endonuclease 1 (Fen1) is a key enzyme for maintaining genetic stability in
eukaryotic genomes. Haploinsufficiency of Fen1 leads to the rapid progression of tumours in …

Flap endonuclease 1 (FEN1) has been shown to remove 5′ overhanging flap
intermediates during base excision repair and to process the 5′ ends of Okazaki fragments …

The structure specific flap endonuclease 1 (FEN1) plays an essential role in long-patch base
excision repair (BER) and in DNA replication. We have generated a fluorescently tagged …

Unlike the most well‐characterized prokaryotic polymerase, E. Coli DNA pol I, none of the
eukaryotic polymerases have their own 5′ to 3′ exonuclease domain for nick translation …

Flap endonuclease 1 (FEN1) proteins, which are present in all kingdoms of life, catalyze the
sequence-independent hydrolysis of the bifurcated nucleic acid intermediates formed during …