Dendrimers as carriers for siRNA delivery and gene silencing: a review
J Wu, W Huang, Z He - The Scientific World Journal, 2013 - Wiley Online Library
RNA interference (RNAi) was first literaturally reported in 1998 and has become rapidly a
promising tool for therapeutic applications in gene therapy. In a typical RNAi process, small …
promising tool for therapeutic applications in gene therapy. In a typical RNAi process, small …
Dendrimers as non-viral vectors for siRNA delivery
There is a tremendous interest in moving siRNA therapeutics into a clinical setting for the
treatment of various diseases. This in itself however depends largely on the availability of …
treatment of various diseases. This in itself however depends largely on the availability of …
Delivering siRNA with dendrimers: In vivo applications
V Leiro, S Duque Santos… - Current Gene Therapy, 2017 - ingentaconnect.com
Over the last decades, gene therapy has emerged as a pioneering therapeutic approach to
treat or prevent several diseases. Among the explored strategies, the short-term silencing of …
treat or prevent several diseases. Among the explored strategies, the short-term silencing of …
siRNA therapy, challenges and underlying perspectives of dendrimer as delivery vector
R Kumar Tekade, R GS Maheshwari… - Current …, 2015 - ingentaconnect.com
siRNA technology presents a helpful means of gene silencing in mammalian cells.
Advancement in the field includes enhanced attentiveness in the characterization of target …
Advancement in the field includes enhanced attentiveness in the characterization of target …
Surface engineered dendrimers in siRNA delivery and gene silencing
Background: Therapeutic efficacy of dreadful diseases like cancer, HIV (Human
Immunodeficiency Virus) can be enhanced by delivering molecules which regulate function …
Immunodeficiency Virus) can be enhanced by delivering molecules which regulate function …
[HTML][HTML] Dendrimers for siRNA delivery
S Biswas, VP Torchilin - Pharmaceuticals, 2013 - mdpi.com
Since the discovery of the “starburst polymer”, later renamed as dendrimer, this class of
polymers has gained considerable attention for numerous biomedical applications, due …
polymers has gained considerable attention for numerous biomedical applications, due …
Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing
Small interfering RNA (siRNA) therapeutics hold great promise to treat a variety of diseases,
as long as they can be delivered safely and effectively into cells. Dendrimers are appealing …
as long as they can be delivered safely and effectively into cells. Dendrimers are appealing …
Efficient siRNA delivery using a polyamidoamine dendrimer with a modified pentaerythritol core
Y Zhang, C Zhou, KJ Kwak, X Wang, B Yung… - Pharmaceutical …, 2012 - Springer
Purpose Delivery of siRNA into cells remains a critical challenge. Our lab has shown a novel
polyamidoamine (PAMAM) dendrimer with modified pentaerythritol derivative core (PD …
polyamidoamine (PAMAM) dendrimer with modified pentaerythritol derivative core (PD …
SiRNA delivery systems based on neutral cross-linked dendrimers
A neutral cross-linked dendritic system is described for use of delivering small interfering
RNA (siRNA) for targeted gene silencing. By replacing the terminal amines with hydrazide …
RNA (siRNA) for targeted gene silencing. By replacing the terminal amines with hydrazide …
An ionizable supramolecular dendrimer nanosystem for effective siRNA delivery with a favorable safety profile
Gene therapy using small interfering RNA (siRNA) is emerging as a novel therapeutic
approach to treat various diseases. However, safe and efficient siRNA delivery still …
approach to treat various diseases. However, safe and efficient siRNA delivery still …