Objectives: To evaluate the practical application and psychometric properties of three health
utility measures in a sample of MS patients with a broad range of neurological disability as …

Background: Patient outcomes in multiple sclerosis (MS) have generally been measured by
their neurological impairment using specific scales such as the Kurtzke Expanded Disability …

Background Quantifying the clinical impact of multiple sclerosis (MS) is one of the most
important determinants for optimizing individual patient care. Useful clinical measures for …

Background: Quality of life instruments provide information that traditional outcome
measures used in studies of multiple sclerosis do not. It is unclear if longer, disease-specific …

Objective The reliability and validity of generic utility measures have not yet been
summarized in people with multiple sclerosis (MS). It is important to assess the psychometric …

Health-related quality of life instruments are expected to be of particular value in routine care
of people with multiple sclerosis (MS), where they may facilitate the detection of disease …

Background Inconsistent use of generic and disease-specific health-related quality of life
(HRQOL) instruments in multiple sclerosis (MS) studies limits cross-country comparability …

Background Responsiveness, defined as the ability to detect a meaningful change, is a core
psychometric property of an instrument measuring quality of life (QoL) rarely reported in …

Background and purpose To determine the value of health‐related quality of life (HRQOL) in
predicting progression of disability in patients with multiple sclerosis (MS) over a period of 2 …

Objectives: Because published utility estimates in multiple sclerosis (MS) are concentrated
in people with moderate to severe disease severity and focus on specific types of MS, we …