1991.-The cellular distribution of muscarinic acetylcboline receptor protein in the frontal
cortex of Alzheimer (AD) patients, age-matched and middle-aged controls was assessed …

The cellular distribution of muscarinic acetylcholine receptor protein in the frontal cortex of
Alzheimer (AD) patients, age-matched and middle-aged controls was assessed …

The cholinergic receptors are classically divided into two kinds, namely the nicotinic
acetylcholine receptor and the muscarinic acetyl-choline receptor. The existence of these …

Cholinergic receptors (muscarinic subtypes M1 and M2, and putative nicotinic binding) have
been examined in the hippocampus obtained at autopsy from a variety of patients with …

The total population of muscarinic receptors and a subpopulation of muscarinic receptors
with high affinity for agonists were measured with [3 H] quinuclidinyl benzilate and [3 H] …

Ligand binding studies show marked reductions of nicotinic, but not of muscarinic binding
sites in Alzheimer's disease. Using monoclonal antibodies we studied …

Muscarinic (cholinergic) receptor binding sites (MRB) were studied by determining the 3H-
QNB binding in four cortical areas and hippocampus of 20 histologically confirmed …

Brain muscarinic M1 and M2 binding sites, as defined by their affinity for pirenzepine, were
studied in 24 regions of 3 normal control brains. For each region, the binding of [3 H] QNB, a …

Cholinergic deficits in Alzheimer disease (AD) have been well documented. Choline
acetyltransferase (ChAt), the synthetic enzyme for acetylcholine (ACh), is consistently …

Alzheimer's disease (AD) is characterized by an extensive degeneration of the cholinergic
system in the human nucleus basalis of Meynert, neocortex and hippocampus (1–5), mainly …