The cholinergic system, particularly the cortically projecting neurons situated in the basal
forebrain, is clearly involved in a variety of human disorders associated with dementia …

Cholinergic nicotinic and muscarinic receptor binding were measured in post mortem
human brain tissue, using low (nM) concentrations of (3 H)-nicotine to detect predominately …

The status of various cholinergic markers was compared in Alzheimer's and Parkinson's
diseases. Rather unexpectedly, similar decrements were observed in choline …

[30][24][8][16]* p< 0-05, tp 0-01,* p 0-001 compared with cont Number of patients in brackets
in the number of receptors (Bmax (fmoV mg prot.) 473+ 21-1 for controls and 352+ 28-0 for …

Nicotinic cholinergic receptors were measured in human frontal cortex using [3 H] nicotine
and [3 H] acetylcholine (in the presence of atropine) as receptor ligands. A parallel marked …

The cellular distribution of nicotinic acetylcholine receptors was studied in the frontal cortex
(area 10) of 1) Alzheimer patients and compared to 2) age-matched and 3) middle-aged …

Different effects of normal aging on muscarinic and nicotinic receptor subtypes were
observed in postmortem brain tissue from different regions of the human brain. A significant …

The status of cholinergic receptors in dementia is related to the question of potential
cholinergic therapy. Whilst muscarinic receptor binding is generally reported to be normal or …

Total muscarinic receptor levels, the levels of the subtypes exhibiting high and low affinity for
pirenzepine, and the high‐and low‐affinity agonist states of the receptor were investigated in …

Much evidence has clearly revealed the existence of marked cholinergic deficits in cortical
and hippocampal areas in Alzheimer's disease. Although not necessarily of etiological …